V.A. Cooperative study of antiplatelet agents in diabetic patients after amputation for gangrene: Unobserved, sudden, and unexpected deaths

John A. Colwell, Stephen F. Bingham, Carlos Abraira, James W. Anderson, John P. Comstock, Hau C. Kwaan, Frank Nuttall

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

We report on unobserved, sudden, and unexpected deaths that occurred in a randomized multicenter trial. The long-term effects of aspirin plus dipyridamole on major vascular outcome variables were studied in 231 non insulin-dependent diabetic men with either a recent amputation for gangrene or active gangrene. Depending upon the definition of sudden death used, there were 14, 22, or 17 deaths in the drug group versus 6, 6, or 3 deaths in the placebo group (p = 0.04, 0.001, or 0.001, respectively). Total deaths from atherosclerotic vascular disease or deaths from all causes did not differ in the two treatment groups. Since this finding of a secondary end point is found only after multiple analyses of the data, it must be interpreted with caution. However, it is suggested that further studies on effects of antiplatelet agents on sudden deaths should be performed.

Original languageEnglish (US)
Pages (from-to)191-197
Number of pages7
JournalJournal of Diabetic Complications
Volume3
Issue number4
DOIs
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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