Vβ-specific activation of T cells by the HIV glycoprotein gp160

P. N. Akolkar, N. Chirmule, B. Gulwani-Akolkar, Savita G Pahwa, V. S. Kalyanaraman, R. Pergolizzi, S. Macphail, J. Silver

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Studies by several groups have suggested that HIV infection in vivo results in a Vβ-specific alteration of the TCR repertoire and that this might play a role in the pathogenesis of AIDS. However, there is very little agreement as to which Vβ segments are affected. In order to circumvent the confounding factors present in vivo we have examined the abilities of both a crude protein extract of HIV and purified gp160 to alter the Vβ repertoire of normal T cells in vitro. We find that both a crude extract of HIV as well as gp160 specifically activate T cells expressing a common set of Vβ segments (Vβ3, 12, 14, 15, and sometimes Vβ17 and 20) in individuals of disparate HLA type. This set of Vβ segments is remarkably similar to those recognized by staphylococcal enterotoxin B and supports the hypothesis that bacterial superantigens produced by opportunistically acquired micro-organisms could have an exacerbating effect in AIDS.

Original languageEnglish
Pages (from-to)487-498
Number of pages12
JournalScandinavian Journal of Immunology
Volume41
Issue number5
StatePublished - Jan 1 1995
Externally publishedYes

Fingerprint

HIV Envelope Protein gp160
Complex Mixtures
Glycoproteins
Acquired Immunodeficiency Syndrome
Human Immunodeficiency Virus Proteins
T-Lymphocytes
Superantigens
HIV Infections
HIV

ASJC Scopus subject areas

  • Immunology

Cite this

Akolkar, P. N., Chirmule, N., Gulwani-Akolkar, B., Pahwa, S. G., Kalyanaraman, V. S., Pergolizzi, R., ... Silver, J. (1995). Vβ-specific activation of T cells by the HIV glycoprotein gp160. Scandinavian Journal of Immunology, 41(5), 487-498.

Vβ-specific activation of T cells by the HIV glycoprotein gp160. / Akolkar, P. N.; Chirmule, N.; Gulwani-Akolkar, B.; Pahwa, Savita G; Kalyanaraman, V. S.; Pergolizzi, R.; Macphail, S.; Silver, J.

In: Scandinavian Journal of Immunology, Vol. 41, No. 5, 01.01.1995, p. 487-498.

Research output: Contribution to journalArticle

Akolkar, PN, Chirmule, N, Gulwani-Akolkar, B, Pahwa, SG, Kalyanaraman, VS, Pergolizzi, R, Macphail, S & Silver, J 1995, 'Vβ-specific activation of T cells by the HIV glycoprotein gp160', Scandinavian Journal of Immunology, vol. 41, no. 5, pp. 487-498.
Akolkar PN, Chirmule N, Gulwani-Akolkar B, Pahwa SG, Kalyanaraman VS, Pergolizzi R et al. Vβ-specific activation of T cells by the HIV glycoprotein gp160. Scandinavian Journal of Immunology. 1995 Jan 1;41(5):487-498.
Akolkar, P. N. ; Chirmule, N. ; Gulwani-Akolkar, B. ; Pahwa, Savita G ; Kalyanaraman, V. S. ; Pergolizzi, R. ; Macphail, S. ; Silver, J. / Vβ-specific activation of T cells by the HIV glycoprotein gp160. In: Scandinavian Journal of Immunology. 1995 ; Vol. 41, No. 5. pp. 487-498.
@article{99c08c904f7a4d40af9054059194c0a5,
title = "Vβ-specific activation of T cells by the HIV glycoprotein gp160",
abstract = "Studies by several groups have suggested that HIV infection in vivo results in a Vβ-specific alteration of the TCR repertoire and that this might play a role in the pathogenesis of AIDS. However, there is very little agreement as to which Vβ segments are affected. In order to circumvent the confounding factors present in vivo we have examined the abilities of both a crude protein extract of HIV and purified gp160 to alter the Vβ repertoire of normal T cells in vitro. We find that both a crude extract of HIV as well as gp160 specifically activate T cells expressing a common set of Vβ segments (Vβ3, 12, 14, 15, and sometimes Vβ17 and 20) in individuals of disparate HLA type. This set of Vβ segments is remarkably similar to those recognized by staphylococcal enterotoxin B and supports the hypothesis that bacterial superantigens produced by opportunistically acquired micro-organisms could have an exacerbating effect in AIDS.",
author = "Akolkar, {P. N.} and N. Chirmule and B. Gulwani-Akolkar and Pahwa, {Savita G} and Kalyanaraman, {V. S.} and R. Pergolizzi and S. Macphail and J. Silver",
year = "1995",
month = "1",
day = "1",
language = "English",
volume = "41",
pages = "487--498",
journal = "Scandinavian Journal of Immunology",
issn = "0300-9475",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Vβ-specific activation of T cells by the HIV glycoprotein gp160

AU - Akolkar, P. N.

AU - Chirmule, N.

AU - Gulwani-Akolkar, B.

AU - Pahwa, Savita G

AU - Kalyanaraman, V. S.

AU - Pergolizzi, R.

AU - Macphail, S.

AU - Silver, J.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - Studies by several groups have suggested that HIV infection in vivo results in a Vβ-specific alteration of the TCR repertoire and that this might play a role in the pathogenesis of AIDS. However, there is very little agreement as to which Vβ segments are affected. In order to circumvent the confounding factors present in vivo we have examined the abilities of both a crude protein extract of HIV and purified gp160 to alter the Vβ repertoire of normal T cells in vitro. We find that both a crude extract of HIV as well as gp160 specifically activate T cells expressing a common set of Vβ segments (Vβ3, 12, 14, 15, and sometimes Vβ17 and 20) in individuals of disparate HLA type. This set of Vβ segments is remarkably similar to those recognized by staphylococcal enterotoxin B and supports the hypothesis that bacterial superantigens produced by opportunistically acquired micro-organisms could have an exacerbating effect in AIDS.

AB - Studies by several groups have suggested that HIV infection in vivo results in a Vβ-specific alteration of the TCR repertoire and that this might play a role in the pathogenesis of AIDS. However, there is very little agreement as to which Vβ segments are affected. In order to circumvent the confounding factors present in vivo we have examined the abilities of both a crude protein extract of HIV and purified gp160 to alter the Vβ repertoire of normal T cells in vitro. We find that both a crude extract of HIV as well as gp160 specifically activate T cells expressing a common set of Vβ segments (Vβ3, 12, 14, 15, and sometimes Vβ17 and 20) in individuals of disparate HLA type. This set of Vβ segments is remarkably similar to those recognized by staphylococcal enterotoxin B and supports the hypothesis that bacterial superantigens produced by opportunistically acquired micro-organisms could have an exacerbating effect in AIDS.

UR - http://www.scopus.com/inward/record.url?scp=0028986894&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028986894&partnerID=8YFLogxK

M3 - Article

VL - 41

SP - 487

EP - 498

JO - Scandinavian Journal of Immunology

JF - Scandinavian Journal of Immunology

SN - 0300-9475

IS - 5

ER -