PURPOSE: To present two cases of uveal melanoma presenting as acute angle-closure glaucoma. DESIGN: Observational case reports. METHODS: Assessment and management of two patients with uveal melanoma presenting with acute angle-closure glaucoma. RESULTS: One patient was initially treated with antiglaucoma medications, and a laser peripheral iridotomy was performed. The second patient had opaque media preventing visualization of the posterior segment, but the presence of an occult mass was suspected as the cause of angle closure. In both cases, B-scan ultrasonography revealed the presence of a tumor causing angle-closure glaucoma. The eyes were enucleated, and the diagnosis of uveal malignant melanoma was confirmed by histopathology. CONCLUSION: Although acute angle-closure as the initial presentation of uveal melanoma is rare, the presence of a uveal melanoma should be suspected in eyes unresponsive to medical therapy, especially in unilateral cases in which the view of the posterior segment is obscured.
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