Uveal melanoma: Genetic aspects

Arun D. Singh, Bertil Damato, Peter Howard, J. William Harbour

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The recent emphasis on the study of pathways and global gene expression changes has yielded exciting insights into the molecular pathogenesis of uveal melanoma. As the transformed uveal melanocyte replicates and progresses to a low-grade neoplasm and eventually a high-grade melanoma, the emerging picture is one of progressive deregulation of key regulatory pathways and a global reversion from melanocytic differentiation to a more embryonic or "epithelioid" phenotype with the capacity to invade and spread. Ongoing work in this field is leading rapidly to the development of novel diagnostic and therapeutic approaches that promise to improve the care of patients with uveal melanoma.

Original languageEnglish
Pages (from-to)85-97
Number of pages13
JournalOphthalmology Clinics of North America
Volume18
Issue number1
DOIs
StatePublished - Mar 1 2005
Externally publishedYes

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Melanocytes
Melanoma
Patient Care
Phenotype
Gene Expression
Neoplasms
Uveal melanoma
Therapeutics

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Uveal melanoma : Genetic aspects. / Singh, Arun D.; Damato, Bertil; Howard, Peter; William Harbour, J.

In: Ophthalmology Clinics of North America, Vol. 18, No. 1, 01.03.2005, p. 85-97.

Research output: Contribution to journalArticle

Singh, Arun D. ; Damato, Bertil ; Howard, Peter ; William Harbour, J. / Uveal melanoma : Genetic aspects. In: Ophthalmology Clinics of North America. 2005 ; Vol. 18, No. 1. pp. 85-97.
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