Uveal melanoma gene expression status post radiotherapy

Aaron S. Gold, Timothy G. Murray, Arnold Markoe, Fiona Ehlies, Azeema Latiff, Andrea Wildner, Ernesto Bermudez

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

ABSTRACT Purpose. Gene expression profiling has been shown to yield two distinct molecular genetic signatures for uveal melanoma. These class designations tend to predict tumor aggressiveness and the likelihood of metastasis. Tumors with a class 1 genetic signature are generally much less aggressive than tumors with a class 2 genetic signature. Gene expression analysis for previously treated uveal melanoma has not yet been reported. The authors report three cases where genetic analysis was successfully obtained from uveal melanoma that was previously treated years earlier with radiotherapy. Case Report. The patients in all three cases received globe-conserving radiotherapy for treatment of choroidal melanoma before gene expression profiling was readily available. The patients in cases 1 and 2 received 125I plaque brachytherapy while the patient in case 3 received proton irradiation therapy. When secondary surgery was necessary to stabilize these eyes from the effects of radiation retinopathy, fine-needle aspiration biopsy was also performed for gene expression profiling. Genomic analysis revealed a class 1 molecular signature for the patient in case 1 and a class 2 molecular signature for the patients in cases 2 and 3. Conclusions. Gene expression profiling for uveal melanoma may be obtained from patients who were previously treated with radiotherapy; however, the implication of these results will benefit from ongoing clinical evaluation.

Original languageEnglish
JournalOptometry and Vision Science
Volume91
Issue number1
DOIs
StatePublished - Jan 14 2014

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Radiotherapy
Gene Expression Profiling
Gene Expression
Proton Therapy
Neoplasms
Radiation Effects
Brachytherapy
Fine Needle Biopsy
Uveal melanoma
Molecular Biology
Melanoma
Neoplasm Metastasis
Therapeutics

Keywords

  • choroidal melanoma
  • gene expression profiling
  • radiation retinopathy
  • radiotherapy
  • retina
  • uveal melanoma

ASJC Scopus subject areas

  • Ophthalmology
  • Optometry
  • Medicine(all)

Cite this

Gold, A. S., Murray, T. G., Markoe, A., Ehlies, F., Latiff, A., Wildner, A., & Bermudez, E. (2014). Uveal melanoma gene expression status post radiotherapy. Optometry and Vision Science, 91(1). https://doi.org/10.1097/OPX.0000000000000111

Uveal melanoma gene expression status post radiotherapy. / Gold, Aaron S.; Murray, Timothy G.; Markoe, Arnold; Ehlies, Fiona; Latiff, Azeema; Wildner, Andrea; Bermudez, Ernesto.

In: Optometry and Vision Science, Vol. 91, No. 1, 14.01.2014.

Research output: Contribution to journalArticle

Gold, AS, Murray, TG, Markoe, A, Ehlies, F, Latiff, A, Wildner, A & Bermudez, E 2014, 'Uveal melanoma gene expression status post radiotherapy', Optometry and Vision Science, vol. 91, no. 1. https://doi.org/10.1097/OPX.0000000000000111
Gold, Aaron S. ; Murray, Timothy G. ; Markoe, Arnold ; Ehlies, Fiona ; Latiff, Azeema ; Wildner, Andrea ; Bermudez, Ernesto. / Uveal melanoma gene expression status post radiotherapy. In: Optometry and Vision Science. 2014 ; Vol. 91, No. 1.
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