UVB phototherapy of the pruritic papular eruption of the acquired immunodeficiency syndrome

Rube J. Pardo, Maria A. Bogaert, Neal S. Penneys, Gerald E. Byrne, Phillip Ruiz

Research output: Contribution to journalArticle

47 Scopus citations

Abstract

Background: Pruritic papular eruption (PPE) is a chronic dermatosis frequently seen in human immunodeficiency virus (HIV)-positive patients. UVB phototherapy has been successfully used to treat a similar inflammatory condition (Ofuji disease) as well as pruritus of systemic origin. Objective: We describe the successful treatment with UVB of seven of eight patients with PPE. Methods: Eight HIV-positive patients with PPE were treated. The number of papules in a specified area of skin and the intensity of pruritus were monitored before, during, and after UVB phototherapy given three times a week. Biopsy specimens were taken before and after therapy and systemic immune function was evaluated. Results: Both the number of papules as well as pruritus decreased after UVB treatment in all but one patient. Immunoperoxidase staining showed a relative decrease in CD4+, CD8+, and CD2+ cells in all samples studied except for the patient noted to be unresponsive to the therapy. Conclusion: UVB phototherapy is effective in the treatment of patients with PPE. This is associated with a significant decrease in inflammation and number of T cells from various subsets within the dermis, thereby implicating these cells in the pathogenesis of this disorder.

Original languageEnglish (US)
Pages (from-to)423-428
Number of pages6
JournalJournal of the American Academy of Dermatology
Volume26
Issue number3
DOIs
StatePublished - Jan 1 1992

ASJC Scopus subject areas

  • Dermatology

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