UV photoprotection by combination topical antioxidants vitamin C and vitamin E

Jing Yi Lin, M. Angelica Selim, Christopher R. Shea, James M Grichnik, Mostafa M. Omar, Nancy A. Monteiro-Riviere, Sheldon R. Pinnell

Research output: Contribution to journalArticle

211 Citations (Scopus)

Abstract

Background: Virtually all plants and animals protect themselves from the sun using vitamins C and E. Objective: The purpose of this study was to see if a combination of topical vitamins C and E is better for UV protection to skin than an equivalent concentration of topical vitamin C or E alone. Methods: We developed a stable aqueous solution of 15% L-ascorbic acid (vitamin C) and 1% α-tocopherol (vitamin E). We applied antioxidant or vehicle solutions to pig skin daily for 4 days. We irradiated (1-5 × minimal erythema dose) control- and antioxidant-treated skin using a solar simulator with a 295-nm band-pass filter. On day 5, we measured antioxidant protection factor, erythema, sunburn cells, and thymine dimers. Results: The combination of 15% L-ascorbic acid and 1% α-tocopherol provided significant protection against erythema and sunburn cell formation; either L-ascorbic acid or 1% α-tocopherol alone also was protective but the combination was superior. Application during 4 days provided progressive protection that yielded an antioxidant protection factor of 4-fold. In addition, the combination of vitamins C and E provided protection against thymine dimer formation. Conclusion: Appreciable photoprotection can be obtained from the combination of topical vitamins C and E. We suggest that these natural products may protect against skin cancer and photoaging.

Original languageEnglish
Pages (from-to)866-874
Number of pages9
JournalJournal of the American Academy of Dermatology
Volume48
Issue number6
DOIs
StatePublished - Jun 1 2003
Externally publishedYes

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Vitamin E
Ascorbic Acid
Antioxidants
Tocopherols
Erythema
Sunburn
Pyrimidine Dimers
Skin
Skin Neoplasms
Solar System
Biological Products
Swine

ASJC Scopus subject areas

  • Dermatology

Cite this

Lin, J. Y., Selim, M. A., Shea, C. R., Grichnik, J. M., Omar, M. M., Monteiro-Riviere, N. A., & Pinnell, S. R. (2003). UV photoprotection by combination topical antioxidants vitamin C and vitamin E. Journal of the American Academy of Dermatology, 48(6), 866-874. https://doi.org/10.1067/mjd.2003.425

UV photoprotection by combination topical antioxidants vitamin C and vitamin E. / Lin, Jing Yi; Selim, M. Angelica; Shea, Christopher R.; Grichnik, James M; Omar, Mostafa M.; Monteiro-Riviere, Nancy A.; Pinnell, Sheldon R.

In: Journal of the American Academy of Dermatology, Vol. 48, No. 6, 01.06.2003, p. 866-874.

Research output: Contribution to journalArticle

Lin, JY, Selim, MA, Shea, CR, Grichnik, JM, Omar, MM, Monteiro-Riviere, NA & Pinnell, SR 2003, 'UV photoprotection by combination topical antioxidants vitamin C and vitamin E', Journal of the American Academy of Dermatology, vol. 48, no. 6, pp. 866-874. https://doi.org/10.1067/mjd.2003.425
Lin, Jing Yi ; Selim, M. Angelica ; Shea, Christopher R. ; Grichnik, James M ; Omar, Mostafa M. ; Monteiro-Riviere, Nancy A. ; Pinnell, Sheldon R. / UV photoprotection by combination topical antioxidants vitamin C and vitamin E. In: Journal of the American Academy of Dermatology. 2003 ; Vol. 48, No. 6. pp. 866-874.
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