Utilization of chromatin remodeling agents for lung cancer therapy

David S. Schrump, Julie A. Hong, Dao M. Nguyen

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

Lung cancer is a disease with enormous global medical and economic impact that remains refractory to conventional treatment modalities. Recent insights regarding mechanisms pertaining to epigenetic regulation of gene expression during malignant transformation, together with the identification of agents that modulate chromatin structure provide new opportunities for the treatment and prevention of this lethal disease.

Original languageEnglish (US)
Pages (from-to)56-64
Number of pages9
JournalCancer Journal
Volume13
Issue number1
DOIs
StatePublished - Jan 1 2007

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Keywords

  • 5-aza-2-deoxycytidine
  • Celecoxib
  • Depsipeptide FK228
  • Epigenetics
  • Flavopiridol
  • Lung cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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