Utility of the MISDEF2 Algorithm and Extent of Fusion in Open Adult Spinal Deformity Surgery With Minimum 2-Year Follow-up

Bo Li, Gregory Hawryluk, Praveen V. Mummaneni, Michael Wang, Ratnesh Mehra, Minghao Wang, Darryl Lau, Rory Mayer, Kai Ming Fu, Dean Chou

Research output: Contribution to journalArticlepeer-review


Objective: Long-segment fusion in adult spinal deformity (ASD) is often needed, but more focal surgeries may provide significant relief with less morbidity. The minimally invasive spinal deformity surgery (MISDEF2) algorithm guides minimally invasive ASD surgery, but it may be useful in open ASD surgery. We classified ASD patients undergoing focal decompression, limited decompression and fusion, and full correction according to MISDEF2 and correlated outcomes. Methods: A retrospective study of ASD patients treated by 2 surgeons at our hospital was performed. Inclusion criteria were: age > 50, minimum 2-year follow-up, and open ASD surgery. Tumor, trauma, and infections were excluded. Patients had open surgery including focal decompression, short segment fusion, or full scoliosis correction. All patients were categorized by MISDEF2 into 4 classes based upon spinopelvic parameters. Perioperative metrics were assessed. Radiographic correction, complications and reoperation were recorded. Results: A total of 136 patients met inclusion criteria. Mean follow-up was 46 ± 15.8 months (range, 24–118 months). Forty-seven underwent full deformity correction, 71 underwent short segment fusion, and 18 underwent decompression alone. There were 24 cases of class I, 66 cases of class II, 23 cases of class III, and 23 cases of class IV patients. Patients in class I and II had perioperative complication rates of 0% and 16. 7% and revision rates of 8% and 21. 2% when undergoing focal decompression or limited fusion. However, class II patients undergoing full correction had higher perioperative complications rate (p = 0. 03) and revision surgery rates (p = 0. 047). This difference was not seen in class III patients (p > 0. 05). All class IV patients underwent full correction, but they had higher perioperative complication rates (p < 0. 019), comparable revision surgery rates (p = 0. 27), and better radiographic realignment (p < 0. 001). In addition, full deformity correction was associated with longer length of stay, increased blood loss, and longer operative time (p < 0. 001). Conclusion: The MISDEF2 algorithm may help guide ASD surgical decision making even in open surgery, with focal treatment used in class I and II patients as a viable alternative and full correction implemented in class IV patients because of severe malalignment. However, class II patients with ASD undergoing full deformity correction do have higher complication rates.

Original languageEnglish (US)
Pages (from-to)824-832
Number of pages9
Issue number4
StatePublished - Dec 2021
Externally publishedYes


  • Adult spinal deformity
  • Adult spinal deformity
  • Complications
  • Minimally invasive surgery
  • Outcomes

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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