Utility of immunophenotypic and immunogenotypic analysis in the study of necrotic lymph nodes

F. Vega, M. D. Lozano, J. Alcalde, F. J. Pardo-Mindan

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

We report a case of complete lymph node necrosis. No specific aetiology could be determined by morphology, but a B lymphoid population and clonal rearrangement of the immunoglobulin heavy chain gene were demonstrated in immunophenotypic and immunogenotypic studies performed using DNA extracted from paraffin embedded necrotic tissue. In the setting of lymph node necrosis, we suggest that immunohistochemical and gene rearrangement studies may provide additional diagnostic information.

Original languageEnglish (US)
Pages (from-to)245-248
Number of pages4
JournalVirchows Archiv
Volume434
Issue number3
DOIs
StatePublished - Apr 29 1999
Externally publishedYes

Keywords

  • Gene rearrangement
  • Immunohistochemistry
  • Lymph node necrosis
  • Malignant lymphoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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