Uterine blood flow in a psychiatric population: Impact of maternal depression, anxiety, and psychotropic medication

Catherine Monk, D. Jeffrey Newport, Jeffrey H. Korotkin, Qi Long, Bettina Knight, Zachary N. Stowe

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Accumulating evidence suggests that fetal exposure to maternal psychiatric symptoms is associated with future risk for psychopathology. One potential pathway is distress-linked constriction in uterine or umbilical blood flow (UBF). With approximately 6.6% of pregnant women taking an antidepressant, an ecologically valid investigation of this hypothesis must consider the potential concomitant influence of pharmacotherapy on UBF. Pregnant women (n = 101) with lifetime histories of mental illness were evaluated every 4 to 6 weeks during gestation for mood symptoms and medication use; women underwent an ultrasound examination for UBF at approximately 25 weeks gestation. No associations were observed between UBF and three assessments of maternal prenatal depression and anxiety (acute: coincident with the UBF scan; proximal: within 2 weeks of the scan; chronic: serial symptom ratings). Chronic and acute use of bupropion was associated with reduced UBF, even after controlling for pregnancy complications. Chronic use of atypical antipsychotics also was associated with decreased UBF. There were no associations between serotonergic antidepressant use and UBF. Contrary to a popular hypothesis, depression and anxiety-associated reductions in UBF may not be a pathway by which risk is conferred during prenatal development. However, while requiring replication, our findings suggest that prenatal bupropion exposure may be associated with reductions in UBF.

Original languageEnglish (US)
Pages (from-to)483-490
Number of pages8
JournalBiological Psychiatry
Issue number6
StatePublished - Sep 15 2012
Externally publishedYes


  • Bupropion
  • SSRIs
  • depression
  • neurobehavioral development
  • pregnancy
  • psychopathology
  • uterine blood flow

ASJC Scopus subject areas

  • Biological Psychiatry


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