HIV infection in children has a uniformly poor prognosis, as it does in adults. As the number of cases in children increases, the incidence of grave complications such as Kaposi sarcoma and opportunistic central nervous system infection may approach the level seen in adults. There remains no cure and even the development of a vaccine may take years of further research. Antifungal and antiprotozoan drugs have had limited success in the symptomatic treatment of these patients. Presently the best hope for significant prolongation of life lies in drugs such as azidothymidine (AZT), which act to interfere with viral replication and its resultant lymphocyte destruction. Prompt diagnosis of the disease can, at least, lead to an improved short-term prognosis. Drug therapy as well as counseling must be instituted as soon as possible. It is therefore of some importance that the level of suspicion be heightened among all physicians, including the general and pediatric radiologist. Although many of the radiologic findings described in this report are nonspecific, certain abnormalities should increase the concern of radiologists, particularly in young infants with the appropriate history and physical findings. These include (1) diffuse esophagitis, (2) rapidly progressive diffuse pulmonary consolidation, (3) diffuse reticulonodular pulmonary infiltrates, (4) intra-abdominal adenopathy, and (5) large intra-abdominal masses not related to the kidney, adrenal gland, or liver.
|Original language||English (US)|
|Number of pages||13|
|Journal||Radiologic Clinics of North America|
|State||Published - Jan 1 1988|
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging