Using genomics to develop novel antibacterial therapeutics

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

As the genomics era matures, the availability of complete microbial genome sequences is facilitating computational approaches to understand bacterial genomes and DNA structure/function relationships. From the genome of pathogens, we can derive invaluable information on potential targets for new antimicrobial agents. Advancements in high-throughput 'omics' technologies and the availability of multiple isolates of the same species have significantly changed the time frame and scope for identifying novel therapeutic targets. This article aims to discuss selected aspects of the bacterial genome, and advocates 'omics'-based techniques to advance the discovery of new therapeutic targets against extracellular bacterial pathogens.

Original languageEnglish (US)
Pages (from-to)340-348
Number of pages9
JournalCritical Reviews in Microbiology
Volume36
Issue number4
DOIs
StatePublished - Nov 2010
Externally publishedYes

Fingerprint

Bacterial Genomes
Genomics
Microbial Genome
Bacterial DNA
Anti-Infective Agents
Genome
Technology
Therapeutics

Keywords

  • Bacteria
  • Bioinformatics
  • Genomics
  • Omics
  • Proteomics

ASJC Scopus subject areas

  • Microbiology
  • Applied Microbiology and Biotechnology

Cite this

Using genomics to develop novel antibacterial therapeutics. / Nagathihalli, Nagaraj; Singh, Om V.

In: Critical Reviews in Microbiology, Vol. 36, No. 4, 11.2010, p. 340-348.

Research output: Contribution to journalArticle

@article{c365bf83a11d4d249048402857002d50,
title = "Using genomics to develop novel antibacterial therapeutics",
abstract = "As the genomics era matures, the availability of complete microbial genome sequences is facilitating computational approaches to understand bacterial genomes and DNA structure/function relationships. From the genome of pathogens, we can derive invaluable information on potential targets for new antimicrobial agents. Advancements in high-throughput 'omics' technologies and the availability of multiple isolates of the same species have significantly changed the time frame and scope for identifying novel therapeutic targets. This article aims to discuss selected aspects of the bacterial genome, and advocates 'omics'-based techniques to advance the discovery of new therapeutic targets against extracellular bacterial pathogens.",
keywords = "Bacteria, Bioinformatics, Genomics, Omics, Proteomics",
author = "Nagaraj Nagathihalli and Singh, {Om V.}",
year = "2010",
month = "11",
doi = "10.3109/1040841X.2010.495941",
language = "English (US)",
volume = "36",
pages = "340--348",
journal = "Critical Reviews in Microbiology",
issn = "1040-841X",
publisher = "Informa Healthcare",
number = "4",

}

TY - JOUR

T1 - Using genomics to develop novel antibacterial therapeutics

AU - Nagathihalli, Nagaraj

AU - Singh, Om V.

PY - 2010/11

Y1 - 2010/11

N2 - As the genomics era matures, the availability of complete microbial genome sequences is facilitating computational approaches to understand bacterial genomes and DNA structure/function relationships. From the genome of pathogens, we can derive invaluable information on potential targets for new antimicrobial agents. Advancements in high-throughput 'omics' technologies and the availability of multiple isolates of the same species have significantly changed the time frame and scope for identifying novel therapeutic targets. This article aims to discuss selected aspects of the bacterial genome, and advocates 'omics'-based techniques to advance the discovery of new therapeutic targets against extracellular bacterial pathogens.

AB - As the genomics era matures, the availability of complete microbial genome sequences is facilitating computational approaches to understand bacterial genomes and DNA structure/function relationships. From the genome of pathogens, we can derive invaluable information on potential targets for new antimicrobial agents. Advancements in high-throughput 'omics' technologies and the availability of multiple isolates of the same species have significantly changed the time frame and scope for identifying novel therapeutic targets. This article aims to discuss selected aspects of the bacterial genome, and advocates 'omics'-based techniques to advance the discovery of new therapeutic targets against extracellular bacterial pathogens.

KW - Bacteria

KW - Bioinformatics

KW - Genomics

KW - Omics

KW - Proteomics

UR - http://www.scopus.com/inward/record.url?scp=77958006685&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77958006685&partnerID=8YFLogxK

U2 - 10.3109/1040841X.2010.495941

DO - 10.3109/1040841X.2010.495941

M3 - Article

C2 - 20670176

AN - SCOPUS:77958006685

VL - 36

SP - 340

EP - 348

JO - Critical Reviews in Microbiology

JF - Critical Reviews in Microbiology

SN - 1040-841X

IS - 4

ER -