Using genetically informed, randomized prevention trials to test etiological hypotheses about child and adolescent drug use and psychopathology

Gene H. Brody, Steven R H Beach, Karl G. Hill, George W. Howe, Guillermo J Prado, Stephanie M. Fullerton

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

In this essay, we describe a new era of public health research in which prevention science principles are combined with genomic science to produce gene × intervention (G×I) research. We note the roles of behavioral and molecular genetics in risk and protective mechanisms for drug use and psychopathology among children and adolescents, and the results of first-generation genetically informed prevention trials are reviewed. We also consider the need for secondgeneration research that focuses on G·I effects on mediators or intermediate processes. This research can be used to further understanding of etiological processes, to identify individual differences in children's and adolescents' responses to risk, and to increase the precision of prevention programs. We note the caveats about using genetic data to select intervention participants.

Original languageEnglish
JournalAmerican Journal of Public Health
Volume103
Issue numberSUPPL.1
DOIs
StatePublished - Oct 1 2013

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Psychopathology
Research
Pharmaceutical Preparations
Behavioral Genetics
Protective Agents
Individuality
Genes
Molecular Biology
Public Health

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

Cite this

Using genetically informed, randomized prevention trials to test etiological hypotheses about child and adolescent drug use and psychopathology. / Brody, Gene H.; Beach, Steven R H; Hill, Karl G.; Howe, George W.; Prado, Guillermo J; Fullerton, Stephanie M.

In: American Journal of Public Health, Vol. 103, No. SUPPL.1, 01.10.2013.

Research output: Contribution to journalArticle

Brody, Gene H. ; Beach, Steven R H ; Hill, Karl G. ; Howe, George W. ; Prado, Guillermo J ; Fullerton, Stephanie M. / Using genetically informed, randomized prevention trials to test etiological hypotheses about child and adolescent drug use and psychopathology. In: American Journal of Public Health. 2013 ; Vol. 103, No. SUPPL.1.
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