Using biosensors to detect the release of serotonin from taste buds during taste stimulation

Y. J. Huang; Y. Maruyama; K. S. Lu; E. Pereira; I. Plonsky; J. E. Baur; D. Wu; S. D. Roper

Using biosensors to detect the release of serotonin from taste buds during taste stimulation

Y. J. Huang, Y. Maruyama, K. S. Lu, E. Pereira, I. Plonsky, J. E. Baur, D. Wu, S. D. Roper

Physiology & Biophysics

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

CHO cells transfected with high-affinity 5HT receptors were used to detect and identify the release of serotonin from taste buds. Taste cells release 5HT when depolarized or when stimulated with bitter, sweet, or sour tastants. Sour- and depolarization-evoked release of 5HT from taste buds is triggered by Ca ²⁺ influx from the extracellular fluid. In contrast, bitter- and sweet-evoked release of 5HT is triggered by Ca²⁺ derived from intracellular stores.

Original language	English (US)
Pages (from-to)	87-96
Number of pages	10
Journal	Archives Italiennes de Biologie
Volume	143
Issue number	2
State	Published - May 2005

ASJC Scopus subject areas

Physiology
Cell Biology

Cite this

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abstract = "CHO cells transfected with high-affinity 5HT receptors were used to detect and identify the release of serotonin from taste buds. Taste cells release 5HT when depolarized or when stimulated with bitter, sweet, or sour tastants. Sour- and depolarization-evoked release of 5HT from taste buds is triggered by Ca 2+ influx from the extracellular fluid. In contrast, bitter- and sweet-evoked release of 5HT is triggered by Ca2+ derived from intracellular stores.",

author = "Huang, {Y. J.} and Y. Maruyama and Lu, {K. S.} and E. Pereira and I. Plonsky and Baur, {J. E.} and D. Wu and Roper, {S. D.}",

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AU - Huang, Y. J.

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AU - Lu, K. S.

AU - Pereira, E.

AU - Plonsky, I.

AU - Baur, J. E.

AU - Wu, D.

AU - Roper, S. D.

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N2 - CHO cells transfected with high-affinity 5HT receptors were used to detect and identify the release of serotonin from taste buds. Taste cells release 5HT when depolarized or when stimulated with bitter, sweet, or sour tastants. Sour- and depolarization-evoked release of 5HT from taste buds is triggered by Ca 2+ influx from the extracellular fluid. In contrast, bitter- and sweet-evoked release of 5HT is triggered by Ca2+ derived from intracellular stores.

AB - CHO cells transfected with high-affinity 5HT receptors were used to detect and identify the release of serotonin from taste buds. Taste cells release 5HT when depolarized or when stimulated with bitter, sweet, or sour tastants. Sour- and depolarization-evoked release of 5HT from taste buds is triggered by Ca 2+ influx from the extracellular fluid. In contrast, bitter- and sweet-evoked release of 5HT is triggered by Ca2+ derived from intracellular stores.

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Using biosensors to detect the release of serotonin from taste buds during taste stimulation

Abstract

ASJC Scopus subject areas

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