Using allele sharing distance for detecting human population stratification

Xiaoyi Gao, Eden R. Martin

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

There is a long history of using allele sharing distance (ASD) and closely related metrics for population stratification analysis. However, the theory for this practical usage has not been reported. In this paper, we describe the theoretical background for using ASD on single nucleotide polymorphism (SNP) genetic data for human population stratification analysis. In showing the proof, we lay the ground work for a general distance-based method for classifying subpopulations using SNPs and ASD. We also show its relation to other closely related distance metrics using HapMap Phase I SNP data.

Original languageEnglish (US)
Pages (from-to)182-191
Number of pages10
JournalHuman Heredity
Volume68
Issue number3
DOIs
StatePublished - Jul 1 2009

Keywords

  • Allele sharing distance
  • Coancestry coefficient
  • Population stratification
  • Single nucleotide polymorphism

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Fingerprint Dive into the research topics of 'Using allele sharing distance for detecting human population stratification'. Together they form a unique fingerprint.

  • Cite this