Abstract
Clinical outcome was analyzed among a group of 39 consecutive patients with coronary artery disease, left ventricular (LV) ejection fractions <30% and arrhythmias that required an automatic implantable cardioverter defibrillator (AICD) in an attempt to better define the role of the device in patients with severely depressed LV function. Twenty-nine (74%) were survivors of out-of-hospital cardiac arrest and 10 (26%) had ventricular tachycardia that was refractory to electrophysiologically guided antiarrhythmic therapy. The study group had the following demographic characteristics: 90% were men, mean age was 64 years (range 41 to 79) and mean LV ejection fraction was 21 ± 4%. Concomitant pharmacotherapy included antiarrhythmic drugs in 31 (79%), vasodilators in 22 (56%) and digoxin in 20 (51%). There was no statistical difference in baseline characteristics between survivors and nonsurvivors. Patients were followed for a mean of 24 months (range 2 to 72) from implantation. The difference between actuarial survival-77% at 1 year and 72% at 2 years-and projected survival without the AICD (patients who survive without appropriate device discharge)-30% at 1 year and 21% at 2 years-was significant (p < 0.01 and <0.05 at 1 and 2 years, respectively). This study suggests that the AICD improves survival in patients with coronary artery disease despite severely depressed LV function.
| Original language | English |
|---|---|
| Pages (from-to) | 812-816 |
| Number of pages | 5 |
| Journal | The American journal of cardiology |
| Volume | 67 |
| Issue number | 9 |
| DOIs | |
| State | Published - Apr 15 1991 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Usefulness of the automatic implantable cardioverter defibrillator in improving survival of patients with severely depressed left ventricular function associated with coronary artery disease. / De Marchena, Eduardo; Chakko, Simon; Fernandez, Pedro; Villa, Augusto; Cooper, Debbie; Wozniak, Paula; Cruz, Jose; Thurer, Richard J; Kessler, Kenneth M.; Myerburg, Robert J.
In: The American journal of cardiology, Vol. 67, No. 9, 15.04.1991, p. 812-816.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Usefulness of the automatic implantable cardioverter defibrillator in improving survival of patients with severely depressed left ventricular function associated with coronary artery disease
AU - De Marchena, Eduardo
AU - Chakko, Simon
AU - Fernandez, Pedro
AU - Villa, Augusto
AU - Cooper, Debbie
AU - Wozniak, Paula
AU - Cruz, Jose
AU - Thurer, Richard J
AU - Kessler, Kenneth M.
AU - Myerburg, Robert J
PY - 1991/4/15
Y1 - 1991/4/15
N2 - Clinical outcome was analyzed among a group of 39 consecutive patients with coronary artery disease, left ventricular (LV) ejection fractions <30% and arrhythmias that required an automatic implantable cardioverter defibrillator (AICD) in an attempt to better define the role of the device in patients with severely depressed LV function. Twenty-nine (74%) were survivors of out-of-hospital cardiac arrest and 10 (26%) had ventricular tachycardia that was refractory to electrophysiologically guided antiarrhythmic therapy. The study group had the following demographic characteristics: 90% were men, mean age was 64 years (range 41 to 79) and mean LV ejection fraction was 21 ± 4%. Concomitant pharmacotherapy included antiarrhythmic drugs in 31 (79%), vasodilators in 22 (56%) and digoxin in 20 (51%). There was no statistical difference in baseline characteristics between survivors and nonsurvivors. Patients were followed for a mean of 24 months (range 2 to 72) from implantation. The difference between actuarial survival-77% at 1 year and 72% at 2 years-and projected survival without the AICD (patients who survive without appropriate device discharge)-30% at 1 year and 21% at 2 years-was significant (p < 0.01 and <0.05 at 1 and 2 years, respectively). This study suggests that the AICD improves survival in patients with coronary artery disease despite severely depressed LV function.
AB - Clinical outcome was analyzed among a group of 39 consecutive patients with coronary artery disease, left ventricular (LV) ejection fractions <30% and arrhythmias that required an automatic implantable cardioverter defibrillator (AICD) in an attempt to better define the role of the device in patients with severely depressed LV function. Twenty-nine (74%) were survivors of out-of-hospital cardiac arrest and 10 (26%) had ventricular tachycardia that was refractory to electrophysiologically guided antiarrhythmic therapy. The study group had the following demographic characteristics: 90% were men, mean age was 64 years (range 41 to 79) and mean LV ejection fraction was 21 ± 4%. Concomitant pharmacotherapy included antiarrhythmic drugs in 31 (79%), vasodilators in 22 (56%) and digoxin in 20 (51%). There was no statistical difference in baseline characteristics between survivors and nonsurvivors. Patients were followed for a mean of 24 months (range 2 to 72) from implantation. The difference between actuarial survival-77% at 1 year and 72% at 2 years-and projected survival without the AICD (patients who survive without appropriate device discharge)-30% at 1 year and 21% at 2 years-was significant (p < 0.01 and <0.05 at 1 and 2 years, respectively). This study suggests that the AICD improves survival in patients with coronary artery disease despite severely depressed LV function.
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U2 - 10.1016/0002-9149(91)90612-O
DO - 10.1016/0002-9149(91)90612-O
M3 - Article
C2 - 2011982
AN - SCOPUS:0025853101
VL - 67
SP - 812
EP - 816
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 9
ER -