Abstract
We have evaluated the usefulness of the tumor colony assay in predicting chemotherapeutic drug response in our cancer patients population. We found that a wide variety of human tumors will produce clonal growth in this in vitro assay. Low growth rates in many of the common human tumors, however, severely restrict the utility of this assay in a large number of cancer patients. A retrospective analysis using the assay to predict anticancer drug response revealed a true-positive predictive rate of 63% and a true-negative predictive rate of 96%. We conclude that if growth stimulants can be developed to enhance clonal growth without altering the predictability of the assay, the tumor colony assay could prove to be extremely useful in selecting appropriate chemotherapy for individual cancer patients.
| Original language | English |
|---|---|
| Pages (from-to) | 1376-1379 |
| Number of pages | 4 |
| Journal | Southern Medical Journal |
| Volume | 76 |
| Issue number | 11 |
| State | Published - Dec 1 1983 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
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Use of tumor colony assay in clinical oncology. / Niell, H. B.; Neely, C. L.; Wood, C. A.; Soloway, M. S.; Maxwell, T. A.; Buxton, B. H.; Dilawari, R. A.; Kim, W. S.
In: Southern Medical Journal, Vol. 76, No. 11, 01.12.1983, p. 1376-1379.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Use of tumor colony assay in clinical oncology
AU - Niell, H. B.
AU - Neely, C. L.
AU - Wood, C. A.
AU - Soloway, M. S.
AU - Maxwell, T. A.
AU - Buxton, B. H.
AU - Dilawari, R. A.
AU - Kim, W. S.
PY - 1983/12/1
Y1 - 1983/12/1
N2 - We have evaluated the usefulness of the tumor colony assay in predicting chemotherapeutic drug response in our cancer patients population. We found that a wide variety of human tumors will produce clonal growth in this in vitro assay. Low growth rates in many of the common human tumors, however, severely restrict the utility of this assay in a large number of cancer patients. A retrospective analysis using the assay to predict anticancer drug response revealed a true-positive predictive rate of 63% and a true-negative predictive rate of 96%. We conclude that if growth stimulants can be developed to enhance clonal growth without altering the predictability of the assay, the tumor colony assay could prove to be extremely useful in selecting appropriate chemotherapy for individual cancer patients.
AB - We have evaluated the usefulness of the tumor colony assay in predicting chemotherapeutic drug response in our cancer patients population. We found that a wide variety of human tumors will produce clonal growth in this in vitro assay. Low growth rates in many of the common human tumors, however, severely restrict the utility of this assay in a large number of cancer patients. A retrospective analysis using the assay to predict anticancer drug response revealed a true-positive predictive rate of 63% and a true-negative predictive rate of 96%. We conclude that if growth stimulants can be developed to enhance clonal growth without altering the predictability of the assay, the tumor colony assay could prove to be extremely useful in selecting appropriate chemotherapy for individual cancer patients.
UR - http://www.scopus.com/inward/record.url?scp=0021025502&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021025502&partnerID=8YFLogxK
M3 - Article
C2 - 6635726
AN - SCOPUS:0021025502
VL - 76
SP - 1376
EP - 1379
JO - Southern Medical Journal
JF - Southern Medical Journal
SN - 0038-4348
IS - 11
ER -