Use of tumor colony assay in clinical oncology

H. B. Niell, C. L. Neely, C. A. Wood, M. S. Soloway, T. A. Maxwell, B. H. Buxton, R. A. Dilawari, W. S. Kim

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Abstract

We have evaluated the usefulness of the tumor colony assay in predicting chemotherapeutic drug response in our cancer patients population. We found that a wide variety of human tumors will produce clonal growth in this in vitro assay. Low growth rates in many of the common human tumors, however, severely restrict the utility of this assay in a large number of cancer patients. A retrospective analysis using the assay to predict anticancer drug response revealed a true-positive predictive rate of 63% and a true-negative predictive rate of 96%. We conclude that if growth stimulants can be developed to enhance clonal growth without altering the predictability of the assay, the tumor colony assay could prove to be extremely useful in selecting appropriate chemotherapy for individual cancer patients.

Original languageEnglish
Pages (from-to)1376-1379
Number of pages4
JournalSouthern Medical Journal
Volume76
Issue number11
StatePublished - Dec 1 1983
Externally publishedYes

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Medical Oncology
Neoplasms
Growth
Pharmaceutical Preparations
Drug Therapy
Population

ASJC Scopus subject areas

  • Medicine(all)

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Niell, H. B., Neely, C. L., Wood, C. A., Soloway, M. S., Maxwell, T. A., Buxton, B. H., ... Kim, W. S. (1983). Use of tumor colony assay in clinical oncology. Southern Medical Journal, 76(11), 1376-1379.

Use of tumor colony assay in clinical oncology. / Niell, H. B.; Neely, C. L.; Wood, C. A.; Soloway, M. S.; Maxwell, T. A.; Buxton, B. H.; Dilawari, R. A.; Kim, W. S.

In: Southern Medical Journal, Vol. 76, No. 11, 01.12.1983, p. 1376-1379.

Research output: Contribution to journalArticle

Niell, HB, Neely, CL, Wood, CA, Soloway, MS, Maxwell, TA, Buxton, BH, Dilawari, RA & Kim, WS 1983, 'Use of tumor colony assay in clinical oncology', Southern Medical Journal, vol. 76, no. 11, pp. 1376-1379.
Niell HB, Neely CL, Wood CA, Soloway MS, Maxwell TA, Buxton BH et al. Use of tumor colony assay in clinical oncology. Southern Medical Journal. 1983 Dec 1;76(11):1376-1379.
Niell, H. B. ; Neely, C. L. ; Wood, C. A. ; Soloway, M. S. ; Maxwell, T. A. ; Buxton, B. H. ; Dilawari, R. A. ; Kim, W. S. / Use of tumor colony assay in clinical oncology. In: Southern Medical Journal. 1983 ; Vol. 76, No. 11. pp. 1376-1379.
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