Use of the mouse vas diferens assay to evaluate the action of somatostatin peptides on gastric acid secretion

C. A. Meyers, A. J. Kastin, Andrew V Schally, D. H. Coy

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Six closely related analogues of somatostatin were tested for their ability to inhibit electrically induced contractions of the mouse vas deferens. Their inhibiting activities tended to parallel their reported effects on gastric acid secretion in vivo, while no correlation to their in vitro growth hormone release-inhibiting activities was observed. It is suggested that information derived from the vas deferens assay may provide a relatively rapid and inexpensive assessment of the effects of somatostatin analogues on gastric acid secretion. The vas deferens assay was also used to test several somatostatin analogues for antagonistic activity, which was not found.

Original languageEnglish
Pages (from-to)21-24
Number of pages4
JournalDigestion
Volume21
Issue number1
StatePublished - Jan 1 1981
Externally publishedYes

Fingerprint

Vas Deferens
Gastric Acid
Somatostatin
Peptides
Growth Hormone

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Use of the mouse vas diferens assay to evaluate the action of somatostatin peptides on gastric acid secretion. / Meyers, C. A.; Kastin, A. J.; Schally, Andrew V; Coy, D. H.

In: Digestion, Vol. 21, No. 1, 01.01.1981, p. 21-24.

Research output: Contribution to journalArticle

@article{6e709a175899449db5357703af50810c,
title = "Use of the mouse vas diferens assay to evaluate the action of somatostatin peptides on gastric acid secretion",
abstract = "Six closely related analogues of somatostatin were tested for their ability to inhibit electrically induced contractions of the mouse vas deferens. Their inhibiting activities tended to parallel their reported effects on gastric acid secretion in vivo, while no correlation to their in vitro growth hormone release-inhibiting activities was observed. It is suggested that information derived from the vas deferens assay may provide a relatively rapid and inexpensive assessment of the effects of somatostatin analogues on gastric acid secretion. The vas deferens assay was also used to test several somatostatin analogues for antagonistic activity, which was not found.",
author = "Meyers, {C. A.} and Kastin, {A. J.} and Schally, {Andrew V} and Coy, {D. H.}",
year = "1981",
month = "1",
day = "1",
language = "English",
volume = "21",
pages = "21--24",
journal = "Digestion",
issn = "0012-2823",
publisher = "S. Karger AG",
number = "1",

}

TY - JOUR

T1 - Use of the mouse vas diferens assay to evaluate the action of somatostatin peptides on gastric acid secretion

AU - Meyers, C. A.

AU - Kastin, A. J.

AU - Schally, Andrew V

AU - Coy, D. H.

PY - 1981/1/1

Y1 - 1981/1/1

N2 - Six closely related analogues of somatostatin were tested for their ability to inhibit electrically induced contractions of the mouse vas deferens. Their inhibiting activities tended to parallel their reported effects on gastric acid secretion in vivo, while no correlation to their in vitro growth hormone release-inhibiting activities was observed. It is suggested that information derived from the vas deferens assay may provide a relatively rapid and inexpensive assessment of the effects of somatostatin analogues on gastric acid secretion. The vas deferens assay was also used to test several somatostatin analogues for antagonistic activity, which was not found.

AB - Six closely related analogues of somatostatin were tested for their ability to inhibit electrically induced contractions of the mouse vas deferens. Their inhibiting activities tended to parallel their reported effects on gastric acid secretion in vivo, while no correlation to their in vitro growth hormone release-inhibiting activities was observed. It is suggested that information derived from the vas deferens assay may provide a relatively rapid and inexpensive assessment of the effects of somatostatin analogues on gastric acid secretion. The vas deferens assay was also used to test several somatostatin analogues for antagonistic activity, which was not found.

UR - http://www.scopus.com/inward/record.url?scp=0019395215&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019395215&partnerID=8YFLogxK

M3 - Article

C2 - 6112182

AN - SCOPUS:0019395215

VL - 21

SP - 21

EP - 24

JO - Digestion

JF - Digestion

SN - 0012-2823

IS - 1

ER -