Use of thallium-201 brain SPECT to differentiate cerebral lymphoma from toxoplasma encephalitis in AIDS patients

A. Ruiz, W. I. Ganz, M. Judith Post, A. Camp, Howard Landy, W. Mallin, George N Sfakianakis

Research output: Contribution to journalArticle

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Abstract

PURPOSE: To determine whether thallium-201 brain single-photon emission CT could be used to make the distinction between central nervous system lymphoma and toxoplasma encephalitis, which may not be possible by routine MR and CT. METHODS: A total of 37 patients with acquired immunodeficiency syndrome who had intracranial mass lesions found during a 9-month prospective study by either MR or CT underwent further evaluation with Tl-201 brain single-photon emission CT. RESULTS: Twelve patients had increased intense focal Tl-201 uptake. All of these patients had either biopsy- or autopsy-proven lymphoma. Twenty-five of the patients studied had no Tl-201 brain uptake in the lesion(s); 24 of these patients had toxoplasma encephalitis on clinical follow-up. One patient with no Tl-201 uptake was found by cerebrospinal fluid analysis to have mycobacterium tuberculosis abscess. CONCLUSION: Patients with acquired immunodeficiency syndrome who have intracranial mass lesions on MR or CT may benefit from Tl-201 brain single-photon emission CT because it can help distinguish between lymphoma and infectious lesions such as toxoplasma encephalitis.

Original languageEnglish
Pages (from-to)1885-1894
Number of pages10
JournalAmerican Journal of Neuroradiology
Volume15
Issue number10
StatePublished - Jan 1 1994

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Thallium
Toxoplasma
Encephalitis
Single-Photon Emission-Computed Tomography
Lymphoma
Acquired Immunodeficiency Syndrome
Brain
Photons
Mycobacterium tuberculosis
Abscess
Cerebrospinal Fluid
Autopsy
Central Nervous System
Prospective Studies
Biopsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Ruiz, A., Ganz, W. I., Judith Post, M., Camp, A., Landy, H., Mallin, W., & Sfakianakis, G. N. (1994). Use of thallium-201 brain SPECT to differentiate cerebral lymphoma from toxoplasma encephalitis in AIDS patients. American Journal of Neuroradiology, 15(10), 1885-1894.

Use of thallium-201 brain SPECT to differentiate cerebral lymphoma from toxoplasma encephalitis in AIDS patients. / Ruiz, A.; Ganz, W. I.; Judith Post, M.; Camp, A.; Landy, Howard; Mallin, W.; Sfakianakis, George N.

In: American Journal of Neuroradiology, Vol. 15, No. 10, 01.01.1994, p. 1885-1894.

Research output: Contribution to journalArticle

Ruiz, A, Ganz, WI, Judith Post, M, Camp, A, Landy, H, Mallin, W & Sfakianakis, GN 1994, 'Use of thallium-201 brain SPECT to differentiate cerebral lymphoma from toxoplasma encephalitis in AIDS patients', American Journal of Neuroradiology, vol. 15, no. 10, pp. 1885-1894.
Ruiz, A. ; Ganz, W. I. ; Judith Post, M. ; Camp, A. ; Landy, Howard ; Mallin, W. ; Sfakianakis, George N. / Use of thallium-201 brain SPECT to differentiate cerebral lymphoma from toxoplasma encephalitis in AIDS patients. In: American Journal of Neuroradiology. 1994 ; Vol. 15, No. 10. pp. 1885-1894.
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AB - PURPOSE: To determine whether thallium-201 brain single-photon emission CT could be used to make the distinction between central nervous system lymphoma and toxoplasma encephalitis, which may not be possible by routine MR and CT. METHODS: A total of 37 patients with acquired immunodeficiency syndrome who had intracranial mass lesions found during a 9-month prospective study by either MR or CT underwent further evaluation with Tl-201 brain single-photon emission CT. RESULTS: Twelve patients had increased intense focal Tl-201 uptake. All of these patients had either biopsy- or autopsy-proven lymphoma. Twenty-five of the patients studied had no Tl-201 brain uptake in the lesion(s); 24 of these patients had toxoplasma encephalitis on clinical follow-up. One patient with no Tl-201 uptake was found by cerebrospinal fluid analysis to have mycobacterium tuberculosis abscess. CONCLUSION: Patients with acquired immunodeficiency syndrome who have intracranial mass lesions on MR or CT may benefit from Tl-201 brain single-photon emission CT because it can help distinguish between lymphoma and infectious lesions such as toxoplasma encephalitis.

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