Use of synthetic luteinizing hormone releasing hormone in treatment of oligospermic men

a preliminary report

L. Schwarzstein, N. J. Aparicio, D. Turner, J. C. Calamera, R. Mancini, Andrew V Schally

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Synthetic luteinizing hormone releasing hormone (LH RH) was administered to four normogonadotropic, oligospermic men (24 to 39 yr of age) who had no endocrinologic, urologic or associated vascular disease, to assess its possible therapeutic value in male infertility. Previous testicular biopsies of these subjects indicated alteration of spermiogenesis only. LH RH (mean dose, 500 μg/day) was administered intramuscularly for 100 to 135 days. Each patient had at least two sperm counts before starting therapy and had one every 20 to 30 days during and for two to five mth after treatment. The sperm count, semen volume, sperm motility and morphology, and seminal plasma concentrations of fructose and citric acid were studied in each semen sample. In three of the four patients, urinary LH and FSH excretion and plasma testosterone levels were also measured. The sperm count increased clearly in two subjects 30 to 80 days after therapy started; the response was small in the third subject and negative in the fourth. The remaining parameters followed variable courses. Libido increased in all subjects. In the post treatment period, the two patients who had shown the best response during treatment experienced a new and abrupt increase in the sperm count which remained well above initial values at the end of follow up. LH RH appears to be of value in the treatment of certain types of oligospermia, but several issues remain unsettled.

Original languageEnglish
Pages (from-to)331-336
Number of pages6
JournalFertility and Sterility
Volume26
Issue number4
StatePublished - Dec 1 1975
Externally publishedYes

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Gonadotropin-Releasing Hormone
Sperm Count
Semen
Therapeutics
Oligospermia
Libido
Sperm Motility
Male Infertility
Spermatogenesis
Fructose
Vascular Diseases
Citric Acid
Testosterone
Biopsy

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Schwarzstein, L., Aparicio, N. J., Turner, D., Calamera, J. C., Mancini, R., & Schally, A. V. (1975). Use of synthetic luteinizing hormone releasing hormone in treatment of oligospermic men: a preliminary report. Fertility and Sterility, 26(4), 331-336.

Use of synthetic luteinizing hormone releasing hormone in treatment of oligospermic men : a preliminary report. / Schwarzstein, L.; Aparicio, N. J.; Turner, D.; Calamera, J. C.; Mancini, R.; Schally, Andrew V.

In: Fertility and Sterility, Vol. 26, No. 4, 01.12.1975, p. 331-336.

Research output: Contribution to journalArticle

Schwarzstein, L, Aparicio, NJ, Turner, D, Calamera, JC, Mancini, R & Schally, AV 1975, 'Use of synthetic luteinizing hormone releasing hormone in treatment of oligospermic men: a preliminary report', Fertility and Sterility, vol. 26, no. 4, pp. 331-336.
Schwarzstein, L. ; Aparicio, N. J. ; Turner, D. ; Calamera, J. C. ; Mancini, R. ; Schally, Andrew V. / Use of synthetic luteinizing hormone releasing hormone in treatment of oligospermic men : a preliminary report. In: Fertility and Sterility. 1975 ; Vol. 26, No. 4. pp. 331-336.
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