Use of superparamagnetic contrast media to suppress signal from flowing spins: Preliminary experience

Jeffrey L. Duerk, Gregory C. Hurst

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


The authors describe their preliminary experience with the use of superparamagnetic magnetic resonance (MR) imaging contrast media for suppression of signal from flowing blood. The goal of this work was to determine if a superparamagnetic contrast agent could successfully eliminate blood signal during cardiac‐gated MR imaging, thereby eliminating or reducing flow artifacts associated with the complex and variable hemodynamics within the heart chambers. Imaging and data analysis were performed in 17 dogs subjected to experimental myocardial infarction as part of a parallel project. Six doses (0.2, 1, 2, 3.5, 4, 5, and 10 mg/kg) of AMI‐25, an experimental contrast agent, were used in the study. Spin‐echo imaging was performed immediately before and every 5 minutes (for an average of 25 minutes) after bolus injection of the contrast agent. Variations in the image signal‐to‐noise ratio relative to a baseline (before injection of contrast agent) image were assessed as a function of dose and time. Preliminary results suggest that a considerable reduction in blood flow artifacts and, hence, increases in image signal‐tonoise ratio can be achieved at doses greater than or equal to 3.5 mg/kg, for approximately 20 minutes after injection. Doses equal to or less than 2 mg/kg and images obtained more than 20 minutes after injection (regardless of dose) did not reliably show hemodynamic artifact suppression.

Original languageEnglish (US)
Pages (from-to)413-417
Number of pages5
JournalJournal of Magnetic Resonance Imaging
Issue number3
StatePublished - 1994
Externally publishedYes


  • Artifact
  • Contrast enhancement
  • Contrast media
  • experimental studies
  • Flow artifact
  • Flow suppression
  • Heart, flow dynamics
  • Heart, MR, 51.12143
  • Iron
  • Vascular studies

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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