Use of simian immunodeficiency viruses for AIDS research

Research output: Contribution to journalArticle

62 Citations (Scopus)

Abstract

Despite frequent statements to the contrary, there are good animal models for AIDS. In this review, we summarize the properties of one of the most useful animal models: infection of rhesus monkeys with simian immunodeficiency virus (SIV). The SIVs are an extensive group of HIV-related lentiviruses of nonhuman primates. They closely resemble the human AIDS viruses, HIV-1 and HIV-2, in both gene sequence and biological properties. Some SIV isolates, most notably those derived from macaques and mangabeyes, induce AIDS in rhesus monkeys in a time frame suitable for laboratory investigation. Rhesus monkeys are not endangered in the wild, they breed well in captivity, and they are available in reasonably large numbers. Study of SIV has already resulted in seminal contributions regarding the origins of the HIVs, AIDS pathogenesis, and vaccine and therapy research. Continued use of SIV systems will be an important weapon in our arsenal against AIDS.

Original languageEnglish (US)
Pages (from-to)301-312
Number of pages12
JournalIntervirology
Volume30
Issue number6
StatePublished - 1989
Externally publishedYes

Fingerprint

Simian Immunodeficiency Virus
Acquired Immunodeficiency Syndrome
Macaca mulatta
HIV
Research
Primate Lentiviruses
Animal Models
Active Immunotherapy
AIDS Vaccines
HIV-2
Weapons
Macaca
HIV-1
Infection
Genes

Keywords

  • AIDS
  • Animal models
  • HIV-1
  • HIV-2
  • Pathogenesis
  • Simian immunodeficiency virus

ASJC Scopus subject areas

  • Virology

Cite this

Use of simian immunodeficiency viruses for AIDS research. / Desrosiers, Ronald Charles; Ringler, D. J.

In: Intervirology, Vol. 30, No. 6, 1989, p. 301-312.

Research output: Contribution to journalArticle

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