The platelet also serves as a carrier for biological substances and drugs. It can accumulate, by selective active transport, 5-hydroxytryptamine, histamine, dopamine, amino acids, adenine, adenosine, serotonin, catecholamines, and it binds angiotensin, hydrocortisone, and other hormones. Also bound are various drugs, including imipramines, vinca alkaloids, and colchicine. In this article we will review the role of the platelet as a vehicle for transport of drugs, particularly the vinca alkaloids, and the application of this property of platelets to management of clinical disorders.
ASJC Scopus subject areas
- Molecular Biology