Use of Platelets as Drug Carriers for the Treatment of Hematologic Diseases

Yeon S. Ahn, William J. Harrington, Ravindra Mylvaganam

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The platelet also serves as a carrier for biological substances and drugs. It can accumulate, by selective active transport, 5-hydroxytryptamine, histamine, dopamine, amino acids, adenine, adenosine, serotonin, catecholamines, and it binds angiotensin, hydrocortisone, and other hormones. Also bound are various drugs, including imipramines, vinca alkaloids, and colchicine. In this article we will review the role of the platelet as a vehicle for transport of drugs, particularly the vinca alkaloids, and the application of this property of platelets to management of clinical disorders.

Original languageEnglish (US)
Pages (from-to)312-325
Number of pages14
JournalMethods in enzymology
Volume149
Issue numberC
DOIs
StatePublished - Jan 1987

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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