Use of older controlled non-heart-beating donors for liver transplantation

Tatsuya Fukumori, Tomoaki Kato, David Levi, Les Olson, Seigo Nishida, Susan Ganz, Noboru Nakamura, Juan Madariaga, Nobuhiro Ohkohchi, Susumu Satomi, Joshua Miller, Andreas Tzakis

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Abstract

Background. Use of liver grafts from non-heartbeating donors (NHBDs) warrants consideration so to expand the donor pool. Because the results of controlled NHBDs (CNHBDs) were acceptable, we have recently tried to expand the criteria to older CNHBDs. Here, we report our experience using liver grafts from older CNHBDs. Methods. We retrospectively studied our donor records from June 1994 through December 2001. CNHBDs were divided into two groups by age: older donors (O) were more than or equal to 55 years old, and younger donors (Y) were less than 55 years old. We compared donor and recipient demographics and peak laboratory values during the first postoperative week. Results. Twenty-five grafts from CNHBDs were transplanted in our center. Five livers were harvested from O (63±6 years) and 20 were from Y (32±15 years). No differences other than age in donor characteristics were noted between O and Y. Mean age of recipients was 50 years in both groups. Mean cold ischemic time (CIT) was 5.4 hours in O and 7.3 hours in Y (P<.05). Peak glutamic oxaloacetic transaminase (U/L), glutamic pyruvic transaminase (U/L), bilirubin (mg/dL), and prothrombin time (sec) during the first postoperative week were 611, 500, 3.9, and 16 in O and 846, 593, 5.9, and 17 in Y. There were no significant differences between the two groups. The graft survival at 1 year was 80% in O and 70% in Y. Conclusions. In our preliminary experience, recipients of liver grafts from older CNHBDs had an outcome equivalent to that of younger CNHBDs. With the strict evaluation of the donors and brief CIT, liver grafts from older CNHBDs may be used to expand the donor pool.

Original languageEnglish
Pages (from-to)1171-1174
Number of pages4
JournalTransplantation
Volume75
Issue number8
DOIs
StatePublished - Apr 27 2003

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Liver Transplantation
Tissue Donors
Transplants
Liver
Cold Ischemia
Prothrombin Time
Graft Survival
Aspartate Aminotransferases
Alanine Transaminase
Bilirubin
Age Groups
Demography

ASJC Scopus subject areas

  • Transplantation
  • Immunology

Cite this

Fukumori, T., Kato, T., Levi, D., Olson, L., Nishida, S., Ganz, S., ... Tzakis, A. (2003). Use of older controlled non-heart-beating donors for liver transplantation. Transplantation, 75(8), 1171-1174. https://doi.org/10.1097/01.TP.0000061785.51689.B0

Use of older controlled non-heart-beating donors for liver transplantation. / Fukumori, Tatsuya; Kato, Tomoaki; Levi, David; Olson, Les; Nishida, Seigo; Ganz, Susan; Nakamura, Noboru; Madariaga, Juan; Ohkohchi, Nobuhiro; Satomi, Susumu; Miller, Joshua; Tzakis, Andreas.

In: Transplantation, Vol. 75, No. 8, 27.04.2003, p. 1171-1174.

Research output: Contribution to journalArticle

Fukumori, T, Kato, T, Levi, D, Olson, L, Nishida, S, Ganz, S, Nakamura, N, Madariaga, J, Ohkohchi, N, Satomi, S, Miller, J & Tzakis, A 2003, 'Use of older controlled non-heart-beating donors for liver transplantation', Transplantation, vol. 75, no. 8, pp. 1171-1174. https://doi.org/10.1097/01.TP.0000061785.51689.B0
Fukumori T, Kato T, Levi D, Olson L, Nishida S, Ganz S et al. Use of older controlled non-heart-beating donors for liver transplantation. Transplantation. 2003 Apr 27;75(8):1171-1174. https://doi.org/10.1097/01.TP.0000061785.51689.B0
Fukumori, Tatsuya ; Kato, Tomoaki ; Levi, David ; Olson, Les ; Nishida, Seigo ; Ganz, Susan ; Nakamura, Noboru ; Madariaga, Juan ; Ohkohchi, Nobuhiro ; Satomi, Susumu ; Miller, Joshua ; Tzakis, Andreas. / Use of older controlled non-heart-beating donors for liver transplantation. In: Transplantation. 2003 ; Vol. 75, No. 8. pp. 1171-1174.
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abstract = "Background. Use of liver grafts from non-heartbeating donors (NHBDs) warrants consideration so to expand the donor pool. Because the results of controlled NHBDs (CNHBDs) were acceptable, we have recently tried to expand the criteria to older CNHBDs. Here, we report our experience using liver grafts from older CNHBDs. Methods. We retrospectively studied our donor records from June 1994 through December 2001. CNHBDs were divided into two groups by age: older donors (O) were more than or equal to 55 years old, and younger donors (Y) were less than 55 years old. We compared donor and recipient demographics and peak laboratory values during the first postoperative week. Results. Twenty-five grafts from CNHBDs were transplanted in our center. Five livers were harvested from O (63±6 years) and 20 were from Y (32±15 years). No differences other than age in donor characteristics were noted between O and Y. Mean age of recipients was 50 years in both groups. Mean cold ischemic time (CIT) was 5.4 hours in O and 7.3 hours in Y (P<.05). Peak glutamic oxaloacetic transaminase (U/L), glutamic pyruvic transaminase (U/L), bilirubin (mg/dL), and prothrombin time (sec) during the first postoperative week were 611, 500, 3.9, and 16 in O and 846, 593, 5.9, and 17 in Y. There were no significant differences between the two groups. The graft survival at 1 year was 80{\%} in O and 70{\%} in Y. Conclusions. In our preliminary experience, recipients of liver grafts from older CNHBDs had an outcome equivalent to that of younger CNHBDs. With the strict evaluation of the donors and brief CIT, liver grafts from older CNHBDs may be used to expand the donor pool.",
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T1 - Use of older controlled non-heart-beating donors for liver transplantation

AU - Fukumori, Tatsuya

AU - Kato, Tomoaki

AU - Levi, David

AU - Olson, Les

AU - Nishida, Seigo

AU - Ganz, Susan

AU - Nakamura, Noboru

AU - Madariaga, Juan

AU - Ohkohchi, Nobuhiro

AU - Satomi, Susumu

AU - Miller, Joshua

AU - Tzakis, Andreas

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N2 - Background. Use of liver grafts from non-heartbeating donors (NHBDs) warrants consideration so to expand the donor pool. Because the results of controlled NHBDs (CNHBDs) were acceptable, we have recently tried to expand the criteria to older CNHBDs. Here, we report our experience using liver grafts from older CNHBDs. Methods. We retrospectively studied our donor records from June 1994 through December 2001. CNHBDs were divided into two groups by age: older donors (O) were more than or equal to 55 years old, and younger donors (Y) were less than 55 years old. We compared donor and recipient demographics and peak laboratory values during the first postoperative week. Results. Twenty-five grafts from CNHBDs were transplanted in our center. Five livers were harvested from O (63±6 years) and 20 were from Y (32±15 years). No differences other than age in donor characteristics were noted between O and Y. Mean age of recipients was 50 years in both groups. Mean cold ischemic time (CIT) was 5.4 hours in O and 7.3 hours in Y (P<.05). Peak glutamic oxaloacetic transaminase (U/L), glutamic pyruvic transaminase (U/L), bilirubin (mg/dL), and prothrombin time (sec) during the first postoperative week were 611, 500, 3.9, and 16 in O and 846, 593, 5.9, and 17 in Y. There were no significant differences between the two groups. The graft survival at 1 year was 80% in O and 70% in Y. Conclusions. In our preliminary experience, recipients of liver grafts from older CNHBDs had an outcome equivalent to that of younger CNHBDs. With the strict evaluation of the donors and brief CIT, liver grafts from older CNHBDs may be used to expand the donor pool.

AB - Background. Use of liver grafts from non-heartbeating donors (NHBDs) warrants consideration so to expand the donor pool. Because the results of controlled NHBDs (CNHBDs) were acceptable, we have recently tried to expand the criteria to older CNHBDs. Here, we report our experience using liver grafts from older CNHBDs. Methods. We retrospectively studied our donor records from June 1994 through December 2001. CNHBDs were divided into two groups by age: older donors (O) were more than or equal to 55 years old, and younger donors (Y) were less than 55 years old. We compared donor and recipient demographics and peak laboratory values during the first postoperative week. Results. Twenty-five grafts from CNHBDs were transplanted in our center. Five livers were harvested from O (63±6 years) and 20 were from Y (32±15 years). No differences other than age in donor characteristics were noted between O and Y. Mean age of recipients was 50 years in both groups. Mean cold ischemic time (CIT) was 5.4 hours in O and 7.3 hours in Y (P<.05). Peak glutamic oxaloacetic transaminase (U/L), glutamic pyruvic transaminase (U/L), bilirubin (mg/dL), and prothrombin time (sec) during the first postoperative week were 611, 500, 3.9, and 16 in O and 846, 593, 5.9, and 17 in Y. There were no significant differences between the two groups. The graft survival at 1 year was 80% in O and 70% in Y. Conclusions. In our preliminary experience, recipients of liver grafts from older CNHBDs had an outcome equivalent to that of younger CNHBDs. With the strict evaluation of the donors and brief CIT, liver grafts from older CNHBDs may be used to expand the donor pool.

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