Use of Mueller matrix colposcopy in the characterization of cervical collagen anisotropy

Joseph Chue-Sang, Nola Holness, Mariacarla Gonzalez, Joan Greaves, Ilyas Saytashev, Susan Stoff, Amir Gandjbakhche, Viktor V. Chernomordik, Gene Burkett, Jessica C. Ramella-Roman

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Annually, about 15 million preterm infants are born in the world. Of these, due to complications resulting from their premature birth, about 1 million would die before the age of five. Since the high incidence of preterm birth (PTB) is partially due to the lack of effective diagnostic modalities, methodologies are needed to determine risk of PTB. We propose a noninvasive tool based on polarized light imaging aimed at measuring the organization of collagen in the cervix. Cervical collagen has been shown to remodel with the approach of parturition. We used a full-field Mueller matrix polarimetric colposcope to assess and compare cervical collagen content and structure in nonpregnant and pregnant women in vivo. Local collagen directional azimuth was used and a total of eight cervices were imaged.

Original languageEnglish (US)
Article number121605
JournalJournal of Biomedical Optics
Issue number12
StatePublished - Dec 1 2018


  • Mueller matrix
  • anisotropy
  • birefringence
  • cervix
  • collagen
  • colposcopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering


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