TY - JOUR
T1 - Use of Mueller matrix colposcopy in the characterization of cervical collagen anisotropy
AU - Chue-Sang, Joseph
AU - Holness, Nola
AU - Gonzalez, Mariacarla
AU - Greaves, Joan
AU - Saytashev, Ilyas
AU - Stoff, Susan
AU - Gandjbakhche, Amir
AU - Chernomordik, Viktor V.
AU - Burkett, Gene
AU - Ramella-Roman, Jessica C.
N1 - Publisher Copyright:
© The Authors.
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Annually, about 15 million preterm infants are born in the world. Of these, due to complications resulting from their premature birth, about 1 million would die before the age of five. Since the high incidence of preterm birth (PTB) is partially due to the lack of effective diagnostic modalities, methodologies are needed to determine risk of PTB. We propose a noninvasive tool based on polarized light imaging aimed at measuring the organization of collagen in the cervix. Cervical collagen has been shown to remodel with the approach of parturition. We used a full-field Mueller matrix polarimetric colposcope to assess and compare cervical collagen content and structure in nonpregnant and pregnant women in vivo. Local collagen directional azimuth was used and a total of eight cervices were imaged.
AB - Annually, about 15 million preterm infants are born in the world. Of these, due to complications resulting from their premature birth, about 1 million would die before the age of five. Since the high incidence of preterm birth (PTB) is partially due to the lack of effective diagnostic modalities, methodologies are needed to determine risk of PTB. We propose a noninvasive tool based on polarized light imaging aimed at measuring the organization of collagen in the cervix. Cervical collagen has been shown to remodel with the approach of parturition. We used a full-field Mueller matrix polarimetric colposcope to assess and compare cervical collagen content and structure in nonpregnant and pregnant women in vivo. Local collagen directional azimuth was used and a total of eight cervices were imaged.
KW - Mueller matrix
KW - anisotropy
KW - birefringence
KW - cervix
KW - collagen
KW - colposcopy
UR - http://www.scopus.com/inward/record.url?scp=85051782896&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85051782896&partnerID=8YFLogxK
U2 - 10.1117/1.JBO.23.12.121605
DO - 10.1117/1.JBO.23.12.121605
M3 - Article
AN - SCOPUS:85051782896
VL - 23
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
SN - 1083-3668
IS - 12
M1 - 121605
ER -