Use of Mueller matrix colposcopy in the characterization of cervical collagen anisotropy

Joseph Chue-Sang, Nola Holness, Mariacarla Gonzalez, Joan Greaves, Ilyas Saytashev, Susan Stoff, Amir Gandjbakhche, Viktor V. Chernomordik, Gene Burkett, Jessica C. Ramella-Roman

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Annually, about 15 million preterm infants are born in the world. Of these, due to complications resulting from their premature birth, about 1 million would die before the age of five. Since the high incidence of preterm birth (PTB) is partially due to the lack of effective diagnostic modalities, methodologies are needed to determine risk of PTB. We propose a noninvasive tool based on polarized light imaging aimed at measuring the organization of collagen in the cervix. Cervical collagen has been shown to remodel with the approach of parturition. We used a full-field Mueller matrix polarimetric colposcope to assess and compare cervical collagen content and structure in nonpregnant and pregnant women in vivo. Local collagen directional azimuth was used and a total of eight cervices were imaged.

Original languageEnglish (US)
Article number121605
JournalJournal of Biomedical Optics
Volume23
Issue number12
DOIs
StatePublished - Dec 1 2018

Fingerprint

collagens
Collagen
Anisotropy
anisotropy
matrices
Light polarization
azimuth
polarized light
incidence
methodology
Imaging techniques

Keywords

  • anisotropy
  • birefringence
  • cervix
  • collagen
  • colposcopy
  • Mueller matrix

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Biomedical Engineering

Cite this

Chue-Sang, J., Holness, N., Gonzalez, M., Greaves, J., Saytashev, I., Stoff, S., ... Ramella-Roman, J. C. (2018). Use of Mueller matrix colposcopy in the characterization of cervical collagen anisotropy. Journal of Biomedical Optics, 23(12), [121605]. https://doi.org/10.1117/1.JBO.23.12.121605

Use of Mueller matrix colposcopy in the characterization of cervical collagen anisotropy. / Chue-Sang, Joseph; Holness, Nola; Gonzalez, Mariacarla; Greaves, Joan; Saytashev, Ilyas; Stoff, Susan; Gandjbakhche, Amir; Chernomordik, Viktor V.; Burkett, Gene; Ramella-Roman, Jessica C.

In: Journal of Biomedical Optics, Vol. 23, No. 12, 121605, 01.12.2018.

Research output: Contribution to journalArticle

Chue-Sang, J, Holness, N, Gonzalez, M, Greaves, J, Saytashev, I, Stoff, S, Gandjbakhche, A, Chernomordik, VV, Burkett, G & Ramella-Roman, JC 2018, 'Use of Mueller matrix colposcopy in the characterization of cervical collagen anisotropy', Journal of Biomedical Optics, vol. 23, no. 12, 121605. https://doi.org/10.1117/1.JBO.23.12.121605
Chue-Sang J, Holness N, Gonzalez M, Greaves J, Saytashev I, Stoff S et al. Use of Mueller matrix colposcopy in the characterization of cervical collagen anisotropy. Journal of Biomedical Optics. 2018 Dec 1;23(12). 121605. https://doi.org/10.1117/1.JBO.23.12.121605
Chue-Sang, Joseph ; Holness, Nola ; Gonzalez, Mariacarla ; Greaves, Joan ; Saytashev, Ilyas ; Stoff, Susan ; Gandjbakhche, Amir ; Chernomordik, Viktor V. ; Burkett, Gene ; Ramella-Roman, Jessica C. / Use of Mueller matrix colposcopy in the characterization of cervical collagen anisotropy. In: Journal of Biomedical Optics. 2018 ; Vol. 23, No. 12.
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