Use of Mueller matrix colposcopy in the characterization of cervical collagen anisotropy

Joseph Chue-Sang; Nola Holness; Mariacarla Gonzalez; Joan Greaves; Ilyas Saytashev; Susan Stoff; Amir Gandjbakhche; Viktor V. Chernomordik; Gene Burkett; Jessica C. Ramella-Roman

doi:10.1117/1.JBO.23.12.121605

Use of Mueller matrix colposcopy in the characterization of cervical collagen anisotropy

Joseph Chue-Sang, Nola Holness, Mariacarla Gonzalez, Joan Greaves, Ilyas Saytashev, Susan Stoff, Amir Gandjbakhche, Viktor V. Chernomordik, Gene Burkett, Jessica C. Ramella-Roman

Obstetrics & Gynecology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Annually, about 15 million preterm infants are born in the world. Of these, due to complications resulting from their premature birth, about 1 million would die before the age of five. Since the high incidence of preterm birth (PTB) is partially due to the lack of effective diagnostic modalities, methodologies are needed to determine risk of PTB. We propose a noninvasive tool based on polarized light imaging aimed at measuring the organization of collagen in the cervix. Cervical collagen has been shown to remodel with the approach of parturition. We used a full-field Mueller matrix polarimetric colposcope to assess and compare cervical collagen content and structure in nonpregnant and pregnant women in vivo. Local collagen directional azimuth was used and a total of eight cervices were imaged.

Original language	English (US)
Article number	121605
Journal	Journal of Biomedical Optics
Volume	23
Issue number	12
DOIs	https://doi.org/10.1117/1.JBO.23.12.121605
State	Published - Dec 1 2018

Keywords

Mueller matrix
anisotropy
birefringence
cervix
collagen
colposcopy

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Biomaterials
Atomic and Molecular Physics, and Optics
Biomedical Engineering

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10.1117/1.JBO.23.12.121605

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Use of Mueller matrix colposcopy in the characterization of cervical collagen anisotropy. / Chue-Sang, Joseph; Holness, Nola; Gonzalez, Mariacarla; Greaves, Joan; Saytashev, Ilyas; Stoff, Susan; Gandjbakhche, Amir; Chernomordik, Viktor V.; Burkett, Gene; Ramella-Roman, Jessica C.

In: Journal of Biomedical Optics, Vol. 23, No. 12, 121605, 01.12.2018.

Research output: Contribution to journal › Article › peer-review

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AU - Stoff, Susan

AU - Gandjbakhche, Amir

AU - Chernomordik, Viktor V.

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