Use of genetic profiling in leprosy to discriminate clinical forms of the disease

Joshua R. Bleharski, Huiying Li, Christoph Meinken, Thomas G. Graeber, Maria Teresa Ochoa, Masahiro Yamamura, Anne Burdick, Euzenir N. Sarno, Manfred Wagner, Martin Röllinghoff, Thomas H. Rea, Marco Colonna, Steffen Stenger, Barry R. Bloom, David Eisenberg, Robert L. Modlin

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132 Scopus citations

Abstract

Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease, Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens.

Original languageEnglish (US)
Pages (from-to)1527-1530
Number of pages4
JournalScience
Volume301
Issue number5639
DOIs
StatePublished - Sep 12 2003

ASJC Scopus subject areas

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    Bleharski, J. R., Li, H., Meinken, C., Graeber, T. G., Ochoa, M. T., Yamamura, M., Burdick, A., Sarno, E. N., Wagner, M., Röllinghoff, M., Rea, T. H., Colonna, M., Stenger, S., Bloom, B. R., Eisenberg, D., & Modlin, R. L. (2003). Use of genetic profiling in leprosy to discriminate clinical forms of the disease. Science, 301(5639), 1527-1530. https://doi.org/10.1126/science.1087785