Use of genetic profiling in leprosy to discriminate clinical forms of the disease

Joshua R. Bleharski, Huiying Li, Christoph Meinken, Thomas G. Graeber, Maria Teresa Ochoa, Masahiro Yamamura, Anne Burdick, Euzenir N. Sarno, Manfred Wagner, Martin Röllinghoff, Thomas H. Rea, Marco Colonna, Steffen Stenger, Barry R. Bloom, David Eisenberg, Robert L. Modlin

Research output: Contribution to journalArticle

128 Citations (Scopus)

Abstract

Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease, Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens.

Original languageEnglish
Pages (from-to)1527-1530
Number of pages4
JournalScience
Volume301
Issue number5639
DOIs
StatePublished - Sep 12 2003

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Leprosy
Immunoglobulins
Leukocytes
Toll-Like Receptors
Immune System Diseases
Gene Expression Profiling
Defense Mechanisms
Interleukin-12
Transcriptome
Interleukin-10
Monocytes
Gene Expression
Infection
Genes

ASJC Scopus subject areas

  • General

Cite this

Bleharski, J. R., Li, H., Meinken, C., Graeber, T. G., Ochoa, M. T., Yamamura, M., ... Modlin, R. L. (2003). Use of genetic profiling in leprosy to discriminate clinical forms of the disease. Science, 301(5639), 1527-1530. https://doi.org/10.1126/science.1087785

Use of genetic profiling in leprosy to discriminate clinical forms of the disease. / Bleharski, Joshua R.; Li, Huiying; Meinken, Christoph; Graeber, Thomas G.; Ochoa, Maria Teresa; Yamamura, Masahiro; Burdick, Anne; Sarno, Euzenir N.; Wagner, Manfred; Röllinghoff, Martin; Rea, Thomas H.; Colonna, Marco; Stenger, Steffen; Bloom, Barry R.; Eisenberg, David; Modlin, Robert L.

In: Science, Vol. 301, No. 5639, 12.09.2003, p. 1527-1530.

Research output: Contribution to journalArticle

Bleharski, JR, Li, H, Meinken, C, Graeber, TG, Ochoa, MT, Yamamura, M, Burdick, A, Sarno, EN, Wagner, M, Röllinghoff, M, Rea, TH, Colonna, M, Stenger, S, Bloom, BR, Eisenberg, D & Modlin, RL 2003, 'Use of genetic profiling in leprosy to discriminate clinical forms of the disease', Science, vol. 301, no. 5639, pp. 1527-1530. https://doi.org/10.1126/science.1087785
Bleharski JR, Li H, Meinken C, Graeber TG, Ochoa MT, Yamamura M et al. Use of genetic profiling in leprosy to discriminate clinical forms of the disease. Science. 2003 Sep 12;301(5639):1527-1530. https://doi.org/10.1126/science.1087785
Bleharski, Joshua R. ; Li, Huiying ; Meinken, Christoph ; Graeber, Thomas G. ; Ochoa, Maria Teresa ; Yamamura, Masahiro ; Burdick, Anne ; Sarno, Euzenir N. ; Wagner, Manfred ; Röllinghoff, Martin ; Rea, Thomas H. ; Colonna, Marco ; Stenger, Steffen ; Bloom, Barry R. ; Eisenberg, David ; Modlin, Robert L. / Use of genetic profiling in leprosy to discriminate clinical forms of the disease. In: Science. 2003 ; Vol. 301, No. 5639. pp. 1527-1530.
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