Use of extracorporeal techniques in the removal of dabigatran

Neeharika Muddana, Culver Thuyanh, Ali Nayer, Khaled Nashar, Luis M. Ortega

Research output: Contribution to journalReview article

Abstract

Dabigatran is a novel direct thrombin inhibitor that has proven effective in the prevention of vascular events in patients with nonvalvular atrial fibrillation. Not much is known about the clearance capability with extracorporeal techniques of dabigatran. This review showcases the pharmacokinetics and a perusal of the current literature regarding cases that involved the clearance of the drug in patients with normal renal function and end-stage renal disease. Renal replacement therapy represents a therapeutic option to eliminate dabigatran and decreased the risk of bleeding in patients undergoing emergent surgical procedures on dabigatran.

Original languageEnglish (US)
Pages (from-to)e485-e488
JournalAmerican journal of therapeutics
Volume23
Issue number2
DOIs
StatePublished - Mar 1 2016

Keywords

  • bleeding
  • dabigatran
  • dialysis
  • renal replacement therapy
  • thrombin inhibitors
  • toxicity

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)

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  • Cite this

    Muddana, N., Thuyanh, C., Nayer, A., Nashar, K., & Ortega, L. M. (2016). Use of extracorporeal techniques in the removal of dabigatran. American journal of therapeutics, 23(2), e485-e488. https://doi.org/10.1097/MJT.0000000000000082