Use of extracorporeal techniques in the removal of dabigatran

Neeharika Muddana; Culver Thuyanh; Ali Nayer; Khaled Nashar; Luis M. Ortega

doi:10.1097/MJT.0000000000000082

Use of extracorporeal techniques in the removal of dabigatran

Neeharika Muddana, Culver Thuyanh, Ali Nayer, Khaled Nashar, Luis M. Ortega

Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Dabigatran is a novel direct thrombin inhibitor that has proven effective in the prevention of vascular events in patients with nonvalvular atrial fibrillation. Not much is known about the clearance capability with extracorporeal techniques of dabigatran. This review showcases the pharmacokinetics and a perusal of the current literature regarding cases that involved the clearance of the drug in patients with normal renal function and end-stage renal disease. Renal replacement therapy represents a therapeutic option to eliminate dabigatran and decreased the risk of bleeding in patients undergoing emergent surgical procedures on dabigatran.

Original language	English (US)
Pages (from-to)	e485-e488
Journal	American journal of therapeutics
Volume	23
Issue number	2
DOIs	https://doi.org/10.1097/MJT.0000000000000082
State	Published - Mar 1 2016

Keywords

bleeding
dabigatran
dialysis
renal replacement therapy
thrombin inhibitors
toxicity

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)

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10.1097/MJT.0000000000000082

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abstract = "Dabigatran is a novel direct thrombin inhibitor that has proven effective in the prevention of vascular events in patients with nonvalvular atrial fibrillation. Not much is known about the clearance capability with extracorporeal techniques of dabigatran. This review showcases the pharmacokinetics and a perusal of the current literature regarding cases that involved the clearance of the drug in patients with normal renal function and end-stage renal disease. Renal replacement therapy represents a therapeutic option to eliminate dabigatran and decreased the risk of bleeding in patients undergoing emergent surgical procedures on dabigatran.",

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AU - Ortega, Luis M.

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AB - Dabigatran is a novel direct thrombin inhibitor that has proven effective in the prevention of vascular events in patients with nonvalvular atrial fibrillation. Not much is known about the clearance capability with extracorporeal techniques of dabigatran. This review showcases the pharmacokinetics and a perusal of the current literature regarding cases that involved the clearance of the drug in patients with normal renal function and end-stage renal disease. Renal replacement therapy represents a therapeutic option to eliminate dabigatran and decreased the risk of bleeding in patients undergoing emergent surgical procedures on dabigatran.

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KW - dialysis

KW - renal replacement therapy

KW - thrombin inhibitors

KW - toxicity

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Use of extracorporeal techniques in the removal of dabigatran

Abstract

Keywords

ASJC Scopus subject areas

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