Use of continuous subcutaneous insulin infusion pump in patients with type 2 diabetes mellitus

Susan Nielsen, Donna Kain, Elizabeth Szudzik, Sandeep Dhindsa, Rajesh Garg, Paresh Dandona

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Purpose: In patients with type 2 diabetes, the control of hyperglycemia is often difficult despite full doses of oral hypoglycemic agents and extremely large doses of insulin. These patients pose a major management problem. The authors therefore investigated whether insulin given as a subcutaneous continuous infusion of insulin (CSII) would result in an improvement in glucose homeostasis. Methods: Four patients with badly controlled type 2 diabetes, on treatment with extremely high doses of insulin and oral hypoglycemic agents, were started on CSII. Results: All four patients had a marked improvement in plasma glucose concentrations with a corresponding fall in HbA1c levels. This improvement was associated with a marked fall in the insulin doses necessary to maintain adequate glucose homeostasis. Conclusions: Since HbA1c levels fell from levels that would be associated with diabetic complications to those at which complications are markedly reduced, we recommend that patients with type 2 diabetes uncontrolled on extremely high doses of insulin be given a trial of treatment with CSII.

Original languageEnglish (US)
Pages (from-to)843-848
Number of pages6
JournalDiabetes Educator
Issue number6
StatePublished - Nov 2005
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Health Professions (miscellaneous)


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