Use of collagen corneal shields versus soft contact lenses to enhance penetration of topical tobramycin

Terrence P. O'Brien, Mark R. Sawusch, James D. Dick, Tracey R. Hamburg, John D. Gottsch

Research output: Contribution to journalArticle

50 Scopus citations

Abstract

We compared the corneal penetration in rabbits of topical tobramycin in the presence of collagen corneal shields and bandage soft contact lenses. A collagen corneal shield was placed on six albino rabbit eyes, while therapeutic soft contact lenses (61.4% poly-2-hydroxyethyl-methacrylate/38.6% water) were placed on six eyes. Four control eyes received no shield or contact lens. Topical tobramycin was applied to all 16 eyes every five minutes for six doses. Samples of aqueous humor were removed at 15 and 60 minutes following the last dose. Collagen corneal shields allowed a significant (P < .05) increase in tobramycin penetration into the anterior chamber at 60 minutes compared with hydrophilic soft contact lenses or controls.

Original languageEnglish (US)
Pages (from-to)505-507
Number of pages3
JournalJournal of cataract and refractive surgery
Volume14
Issue number5
DOIs
StatePublished - Jan 1 1988
Externally publishedYes

Keywords

  • collagen corneal shield
  • soft contact lens
  • tobramycin

ASJC Scopus subject areas

  • Surgery
  • Ophthalmology
  • Sensory Systems

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