Use of changes in plasma levels of human immunodeficiency virus type 1 RNA to assess the clinical benefit of antiretroviral therapy

Ian C. Marschner, Ann C. Collier, Robert W. Coombs, Richard T. D'Aquila, Victor DeGruttola, Margaret A. Fischl, Scott M. Hammer, Michael D. Hughes, Victoria A. Johnson, David A. Katzenstein, Douglas D. Richman, Laura M. Smeaton, Stephen A. Spector, Michael S. Saag

Research output: Contribution to journalArticle

188 Scopus citations

Abstract

Data from 1330 human immunodeficiency virus type 1 (HIV-1)-infected patients enrolled in seven antiretroviral treatment trials were analyzed to characterize the clinical benefit of treatment-mediated reductions in plasma HIV-1 RNA levels. The risk of a new AIDS-defining event or death was reduced proportionally to the magnitude of the reduction of the HIV-1 RNA level during the first 6 months of therapy. Pretherapy HIV-1 RNA levels were prognostic independently of on-therapy levels. In addition, the reduction in risk associated with any given reduction of the level of HIV-1 RNA did not vary by pretherapy level. Having either a reduction in HIV-1 RNA level or an increase in CD4+ lymphocyte count, or both, was associated with a delay in clinical disease progression. This indicates that patient prognosis should be assessed using both HIV-1 RNA and CD4+ lymphocyte responses to therapy.

Original languageEnglish (US)
Pages (from-to)40-47
Number of pages8
JournalJournal of Infectious Diseases
Volume177
Issue number1
DOIs
StatePublished - Jan 1 1998
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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    Marschner, I. C., Collier, A. C., Coombs, R. W., D'Aquila, R. T., DeGruttola, V., Fischl, M. A., Hammer, S. M., Hughes, M. D., Johnson, V. A., Katzenstein, D. A., Richman, D. D., Smeaton, L. M., Spector, S. A., & Saag, M. S. (1998). Use of changes in plasma levels of human immunodeficiency virus type 1 RNA to assess the clinical benefit of antiretroviral therapy. Journal of Infectious Diseases, 177(1), 40-47. https://doi.org/10.1086/513823