Use of cardiac troponin T levels as an indicator of doxorubicin-induced cardiotoxicity

Eugene H. Herman, Steven E Lipshultz, Nader Rifai, Jun Zhang, Thomas Papoian, Zu Xi Yu, Kazuyo Takeda, Victor J. Ferrans

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

The release of cardiac troponin T (cTnT) as a biomarker of doxorubicin- induced chronic cardiac injury was evaluated in the spontaneously hypertensive rat (SHR) model. Elevations in serum levels of cTnT and decreased immunohistochemical staining of heart sections for this protein were noted in SHRs treated with cumulative doses of doxorubicin (7 mg/kg) that induced only minimal histological alterations in myocytes. Concentrations of cTnT were fUrther elevated, coincident with reduced immunohistochemical staining, in SHRs given 10-12 mg/kg doxorubicin. Thus, monitoring serum levels of cTnT can detect doxorubicin-induced myocyte damage in SHR and may prove useful for the noninvasive evaluation of this toxicity in humans.

Original languageEnglish
Pages (from-to)195-197
Number of pages3
JournalCancer Research
Volume58
Issue number2
StatePublished - Jan 15 1998
Externally publishedYes

Fingerprint

Troponin T
Doxorubicin
Inbred SHR Rats
Muscle Cells
Staining and Labeling
Serum
Biomarkers
Cardiotoxicity
Wounds and Injuries
Proteins

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Herman, E. H., Lipshultz, S. E., Rifai, N., Zhang, J., Papoian, T., Yu, Z. X., ... Ferrans, V. J. (1998). Use of cardiac troponin T levels as an indicator of doxorubicin-induced cardiotoxicity. Cancer Research, 58(2), 195-197.

Use of cardiac troponin T levels as an indicator of doxorubicin-induced cardiotoxicity. / Herman, Eugene H.; Lipshultz, Steven E; Rifai, Nader; Zhang, Jun; Papoian, Thomas; Yu, Zu Xi; Takeda, Kazuyo; Ferrans, Victor J.

In: Cancer Research, Vol. 58, No. 2, 15.01.1998, p. 195-197.

Research output: Contribution to journalArticle

Herman, EH, Lipshultz, SE, Rifai, N, Zhang, J, Papoian, T, Yu, ZX, Takeda, K & Ferrans, VJ 1998, 'Use of cardiac troponin T levels as an indicator of doxorubicin-induced cardiotoxicity', Cancer Research, vol. 58, no. 2, pp. 195-197.
Herman EH, Lipshultz SE, Rifai N, Zhang J, Papoian T, Yu ZX et al. Use of cardiac troponin T levels as an indicator of doxorubicin-induced cardiotoxicity. Cancer Research. 1998 Jan 15;58(2):195-197.
Herman, Eugene H. ; Lipshultz, Steven E ; Rifai, Nader ; Zhang, Jun ; Papoian, Thomas ; Yu, Zu Xi ; Takeda, Kazuyo ; Ferrans, Victor J. / Use of cardiac troponin T levels as an indicator of doxorubicin-induced cardiotoxicity. In: Cancer Research. 1998 ; Vol. 58, No. 2. pp. 195-197.
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