Abstract
Colitis-associated cancer (CAC) can develop in patients with inflammatory bowel disease with long-term uncontrolled inflammation. The mutational history and tumor microenvironment observed in CAC patients is distinct from that observed in sporadic colon cancer and suggests a different etiology. Recently, much attention has been focused on understanding the cellular origin of cancer and the cancer stem cells, which is key to growth and progression. Cancer stem cells are often chemo-resistant making them attractive targets for improving patient outcomes. New techniques have rapidly been evolving allowing for a better understanding of the normal intestinal stem cell function and behavior in the niche. Use of these new technologies will be crucial to understanding cancer stem cells in both sporadic and CAC. In this review, we will explore emerging methods related to the study of normal and cancer stem cells in the intestine, and examine potential avenues of investigation and application to understanding the pathogenesis of CAC.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 976-983 |
| Number of pages | 8 |
| Journal | Inflammatory Bowel Diseases |
| Volume | 22 |
| Issue number | 4 |
| DOIs | |
| State | Published - Mar 9 2016 |
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Keywords
- APC
- colitis-associated cancer
- colonoid
- enteroid
- inflammation
- Lgr5
- stem cells
- β-catenin
ASJC Scopus subject areas
- Gastroenterology
- Immunology and Allergy
Cite this
Use of cancer stem cells to investigate the pathogenesis of colitis-associated cancer. / Davies, Julie M.; Santaolalla, Rebeca; Abreu, Maria T.
In: Inflammatory Bowel Diseases, Vol. 22, No. 4, 09.03.2016, p. 976-983.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Use of cancer stem cells to investigate the pathogenesis of colitis-associated cancer
AU - Davies, Julie M.
AU - Santaolalla, Rebeca
AU - Abreu, Maria T
PY - 2016/3/9
Y1 - 2016/3/9
N2 - Colitis-associated cancer (CAC) can develop in patients with inflammatory bowel disease with long-term uncontrolled inflammation. The mutational history and tumor microenvironment observed in CAC patients is distinct from that observed in sporadic colon cancer and suggests a different etiology. Recently, much attention has been focused on understanding the cellular origin of cancer and the cancer stem cells, which is key to growth and progression. Cancer stem cells are often chemo-resistant making them attractive targets for improving patient outcomes. New techniques have rapidly been evolving allowing for a better understanding of the normal intestinal stem cell function and behavior in the niche. Use of these new technologies will be crucial to understanding cancer stem cells in both sporadic and CAC. In this review, we will explore emerging methods related to the study of normal and cancer stem cells in the intestine, and examine potential avenues of investigation and application to understanding the pathogenesis of CAC.
AB - Colitis-associated cancer (CAC) can develop in patients with inflammatory bowel disease with long-term uncontrolled inflammation. The mutational history and tumor microenvironment observed in CAC patients is distinct from that observed in sporadic colon cancer and suggests a different etiology. Recently, much attention has been focused on understanding the cellular origin of cancer and the cancer stem cells, which is key to growth and progression. Cancer stem cells are often chemo-resistant making them attractive targets for improving patient outcomes. New techniques have rapidly been evolving allowing for a better understanding of the normal intestinal stem cell function and behavior in the niche. Use of these new technologies will be crucial to understanding cancer stem cells in both sporadic and CAC. In this review, we will explore emerging methods related to the study of normal and cancer stem cells in the intestine, and examine potential avenues of investigation and application to understanding the pathogenesis of CAC.
KW - APC
KW - colitis-associated cancer
KW - colonoid
KW - enteroid
KW - inflammation
KW - Lgr5
KW - stem cells
KW - β-catenin
UR - http://www.scopus.com/inward/record.url?scp=84962269057&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84962269057&partnerID=8YFLogxK
U2 - 10.1097/MIB.0000000000000756
DO - 10.1097/MIB.0000000000000756
M3 - Article
C2 - 26963566
AN - SCOPUS:84962269057
VL - 22
SP - 976
EP - 983
JO - Inflammatory Bowel Diseases
JF - Inflammatory Bowel Diseases
SN - 1078-0998
IS - 4
ER -