Use of antifibrosis agents and glaucoma drainage devices in the American and Japanese Glaucoma Societies

Philip P. Chen, Tetsuya Yamamoto, Akira Sawada, Richard K. Parrish, Yoshiaki Kitazawa

Research output: Contribution to journalArticlepeer-review

113 Scopus citations


Purpose: To investigate practice patterns among glaucoma subspecialists in the American Glaucoma Society (AGS) and the Japanese Glaucoma Society (JGS), regarding use of antifibrosis agents and glaucoma drainage devices. Methods: An anonymous survey incorporating 10 clinical situations was mailed to all AGS and JGS members in December 1995. Results: Half of the AGS (105 of 210) and JGS (25 of 50) members returned surveys. Most respondents (51-87%) preferred trabeculectomy with adjunctive mitomycin for all 10 clinical situations. Mitomycin concentrations varied from 0.1 to 0.8 mg/ml (range of means for 10 situations 0.31-0.39 mg/ml) and intraoperative application times ranged from 5 s to 7 min (range of means for 10 situations 2.5-4.6 min). Preferences for either no antifibrosis agent (up to 39%) or 5-fluorouracil (up to 29%) were highest in primary trabeculectomy. Thirty-seven percent to 64% of AGS members used glaucoma drainage devices, especially after complicated postsurgical glaucomas (after penetrating keratoplasty, scleral buckling, or pars plana vitrectomy) and in neovascular glaucoma, but few JGS members used them. Large differences between university- and private practice-based AGS members were found only in mitomycin use for primary trabeculectomy (33% vs. 52%, respectively; p = 0.07) and for complicated postsurgical glaucomas (46% vs. 70%, respectively; p = 0.03), Conclusions: Trabeculectomy with mitomycin was the preferred surgical procedure among AGS and JGS members in the clinical situations surveyed. Mitomycin concentration and time of application varied widely. Many respondents used 5-fluorouracil or no antimetabolite in primary trabeculectomy, Glaucoma drainage devices were widely used for complicated glaucomas in the United States.

Original languageEnglish (US)
Pages (from-to)192-196
Number of pages5
JournalJournal of glaucoma
Issue number3
StatePublished - Jun 1997


  • 5-fluorouracil
  • American Glaucoma Society
  • Glaucoma drainage device
  • Japanese Glaucoma Society
  • Mitomycin
  • Survey
  • Trabeculectomy

ASJC Scopus subject areas

  • Ophthalmology


Dive into the research topics of 'Use of antifibrosis agents and glaucoma drainage devices in the American and Japanese Glaucoma Societies'. Together they form a unique fingerprint.

Cite this