Abstract
A major diagnostic intervention in the consideration of many patients suspected to have primary immunodeficiency diseases (PIDDs) is the application and interpretation of vaccination. Specifically, the antibody response to antigenic challenge with vaccines can provide substantive insight into the status of human immune function. There are numerous vaccines that are commonly used in healthy individuals, as well as others that are available for specialized applications. Both can potentially be used to facilitate consideration of PIDD. However, the application of vaccines and interpretation of antibody responses in this context are complex. These rely on consideration of numerous existing specific studies, interpolation of data from healthy populations, current diagnostic guidelines, and expert subspecialist practice. This document represents an attempt of a working group of the American Academy of Allergy, Asthma & Immunology to provide further guidance and synthesis in this use of vaccination for diagnostic purposes in consideration of PIDD, as well as to identify key areas for further research.
| Original language | English |
|---|---|
| Journal | Journal of Allergy and Clinical Immunology |
| Volume | 130 |
| Issue number | 3 SUPPL. |
| DOIs | |
| State | Published - Sep 1 2012 |
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Keywords
- antibody deficiency
- antigen challenge
- common variable immunodeficiency
- diagnosis
- guideline
- neoantigen
- primary immunodeficiency
- specific antibody deficiency
- Vaccines
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
Cite this
Use and interpretation of diagnostic vaccination in primary immunodeficiency : A working group report of the Basic and Clinical Immunology Interest Section of the American Academy of Allergy, Asthma & Immunology. / Orange, Jordan S.; Ballow, Mark; Stiehm, E. Richard; Ballas, Zuhair K.; Chinen, Javier; De La Morena, Maite; Kumararatne, Dinakantha; Harville, Terry O.; Hesterberg, Paul; Koleilat, Majed; McGhee, Sean; Perez, Elena E.; Raasch, Jason; Scherzer, Rebecca; Schroeder, Harry; Seroogy, Christine; Huissoon, Aarnoud; Sorensen, Ricardo U.; Katial, Rohit.
In: Journal of Allergy and Clinical Immunology, Vol. 130, No. 3 SUPPL., 01.09.2012.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Use and interpretation of diagnostic vaccination in primary immunodeficiency
T2 - A working group report of the Basic and Clinical Immunology Interest Section of the American Academy of Allergy, Asthma & Immunology
AU - Orange, Jordan S.
AU - Ballow, Mark
AU - Stiehm, E. Richard
AU - Ballas, Zuhair K.
AU - Chinen, Javier
AU - De La Morena, Maite
AU - Kumararatne, Dinakantha
AU - Harville, Terry O.
AU - Hesterberg, Paul
AU - Koleilat, Majed
AU - McGhee, Sean
AU - Perez, Elena E.
AU - Raasch, Jason
AU - Scherzer, Rebecca
AU - Schroeder, Harry
AU - Seroogy, Christine
AU - Huissoon, Aarnoud
AU - Sorensen, Ricardo U.
AU - Katial, Rohit
PY - 2012/9/1
Y1 - 2012/9/1
N2 - A major diagnostic intervention in the consideration of many patients suspected to have primary immunodeficiency diseases (PIDDs) is the application and interpretation of vaccination. Specifically, the antibody response to antigenic challenge with vaccines can provide substantive insight into the status of human immune function. There are numerous vaccines that are commonly used in healthy individuals, as well as others that are available for specialized applications. Both can potentially be used to facilitate consideration of PIDD. However, the application of vaccines and interpretation of antibody responses in this context are complex. These rely on consideration of numerous existing specific studies, interpolation of data from healthy populations, current diagnostic guidelines, and expert subspecialist practice. This document represents an attempt of a working group of the American Academy of Allergy, Asthma & Immunology to provide further guidance and synthesis in this use of vaccination for diagnostic purposes in consideration of PIDD, as well as to identify key areas for further research.
AB - A major diagnostic intervention in the consideration of many patients suspected to have primary immunodeficiency diseases (PIDDs) is the application and interpretation of vaccination. Specifically, the antibody response to antigenic challenge with vaccines can provide substantive insight into the status of human immune function. There are numerous vaccines that are commonly used in healthy individuals, as well as others that are available for specialized applications. Both can potentially be used to facilitate consideration of PIDD. However, the application of vaccines and interpretation of antibody responses in this context are complex. These rely on consideration of numerous existing specific studies, interpolation of data from healthy populations, current diagnostic guidelines, and expert subspecialist practice. This document represents an attempt of a working group of the American Academy of Allergy, Asthma & Immunology to provide further guidance and synthesis in this use of vaccination for diagnostic purposes in consideration of PIDD, as well as to identify key areas for further research.
KW - antibody deficiency
KW - antigen challenge
KW - common variable immunodeficiency
KW - diagnosis
KW - guideline
KW - neoantigen
KW - primary immunodeficiency
KW - specific antibody deficiency
KW - Vaccines
UR - http://www.scopus.com/inward/record.url?scp=84862865305&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862865305&partnerID=8YFLogxK
U2 - 10.1016/j.jaci.2012.07.002
DO - 10.1016/j.jaci.2012.07.002
M3 - Article
VL - 130
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
SN - 0091-6749
IS - 3 SUPPL.
ER -