US-guided core-needle biopsy of the breast: How many specimens are necessary?

Joel Fishman, Clara Milikowski, Rajeev Ramsinghani, M. Victoria Velasquez, Galit Aviram

Research output: Contribution to journalArticle

105 Citations (Scopus)

Abstract

PURPOSE: To analyze the diagnostic yield for each specimen obtained at 14-gauge ultrasonography (US)-guided breast biopsy and compare these findings with mass, procedural, and specimen characteristics that could affect yield. MATERIALS AND METHODS: Seventy-three consecutive biopsies of breast masses were performed by using a 14-gauge handheld biopsy device. Each specimen was graded for whether it was nonfragmented or fragmented and for whether it sank or floated, and each pass was graded for whether or not the needle passed through the lesion. Each specimen was mounted on a separate slide. A pathologist who was unaware of the final diagnoses reviewed the slides in random order. A diagnosis was determined for each specimen whenever possible, and diagnostic yield was calculated as a function of number of passes. The Fisher exact test was used to compare yield for different specimen characteristics. RESULTS: Fourteen (19%) lesions were malignant and 59 (81%) were benign. Cells indicating the final diagnosis were contained in 249 (75%) of 334 specimens. Cells indicating the diagnosis were contained in the first specimen in 51 (70%) lesions, in the second specimen in 67 (92%), in the third specimen in 70 (96%), and in the fourth specimen in 73 (100%). Of the 14 malignancies, 13 (93%) were diagnosed with cells contained in the first or second specimen; one cancer (ductal carcinoma in situ) was diagnosed with cells contained in the fourth specimen. Specimens that were nonfragmented (P < .001) and sank (P < .001) showed correlation with being diagnostic, but needle visualization within the lesion did not. CONCLUSION: A minimum of four specimens, preferably those that are nonfragmented and that sink, should be obtained with 14-gauge US-guided breast biopsy.

Original languageEnglish
Pages (from-to)779-782
Number of pages4
JournalRadiology
Volume226
Issue number3
DOIs
StatePublished - Mar 1 2003

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Large-Core Needle Biopsy
Ultrasonography
Breast
Mammary Ultrasonography
Biopsy
Needles
Carcinoma, Intraductal, Noninfiltrating
Neoplasms
Equipment and Supplies

Keywords

  • Breast neoplasms, diagnosis
  • Breast, biopsy
  • Breast, US

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

US-guided core-needle biopsy of the breast : How many specimens are necessary? / Fishman, Joel; Milikowski, Clara; Ramsinghani, Rajeev; Velasquez, M. Victoria; Aviram, Galit.

In: Radiology, Vol. 226, No. 3, 01.03.2003, p. 779-782.

Research output: Contribution to journalArticle

Fishman, Joel ; Milikowski, Clara ; Ramsinghani, Rajeev ; Velasquez, M. Victoria ; Aviram, Galit. / US-guided core-needle biopsy of the breast : How many specimens are necessary?. In: Radiology. 2003 ; Vol. 226, No. 3. pp. 779-782.
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abstract = "PURPOSE: To analyze the diagnostic yield for each specimen obtained at 14-gauge ultrasonography (US)-guided breast biopsy and compare these findings with mass, procedural, and specimen characteristics that could affect yield. MATERIALS AND METHODS: Seventy-three consecutive biopsies of breast masses were performed by using a 14-gauge handheld biopsy device. Each specimen was graded for whether it was nonfragmented or fragmented and for whether it sank or floated, and each pass was graded for whether or not the needle passed through the lesion. Each specimen was mounted on a separate slide. A pathologist who was unaware of the final diagnoses reviewed the slides in random order. A diagnosis was determined for each specimen whenever possible, and diagnostic yield was calculated as a function of number of passes. The Fisher exact test was used to compare yield for different specimen characteristics. RESULTS: Fourteen (19{\%}) lesions were malignant and 59 (81{\%}) were benign. Cells indicating the final diagnosis were contained in 249 (75{\%}) of 334 specimens. Cells indicating the diagnosis were contained in the first specimen in 51 (70{\%}) lesions, in the second specimen in 67 (92{\%}), in the third specimen in 70 (96{\%}), and in the fourth specimen in 73 (100{\%}). Of the 14 malignancies, 13 (93{\%}) were diagnosed with cells contained in the first or second specimen; one cancer (ductal carcinoma in situ) was diagnosed with cells contained in the fourth specimen. Specimens that were nonfragmented (P < .001) and sank (P < .001) showed correlation with being diagnostic, but needle visualization within the lesion did not. CONCLUSION: A minimum of four specimens, preferably those that are nonfragmented and that sink, should be obtained with 14-gauge US-guided breast biopsy.",
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N2 - PURPOSE: To analyze the diagnostic yield for each specimen obtained at 14-gauge ultrasonography (US)-guided breast biopsy and compare these findings with mass, procedural, and specimen characteristics that could affect yield. MATERIALS AND METHODS: Seventy-three consecutive biopsies of breast masses were performed by using a 14-gauge handheld biopsy device. Each specimen was graded for whether it was nonfragmented or fragmented and for whether it sank or floated, and each pass was graded for whether or not the needle passed through the lesion. Each specimen was mounted on a separate slide. A pathologist who was unaware of the final diagnoses reviewed the slides in random order. A diagnosis was determined for each specimen whenever possible, and diagnostic yield was calculated as a function of number of passes. The Fisher exact test was used to compare yield for different specimen characteristics. RESULTS: Fourteen (19%) lesions were malignant and 59 (81%) were benign. Cells indicating the final diagnosis were contained in 249 (75%) of 334 specimens. Cells indicating the diagnosis were contained in the first specimen in 51 (70%) lesions, in the second specimen in 67 (92%), in the third specimen in 70 (96%), and in the fourth specimen in 73 (100%). Of the 14 malignancies, 13 (93%) were diagnosed with cells contained in the first or second specimen; one cancer (ductal carcinoma in situ) was diagnosed with cells contained in the fourth specimen. Specimens that were nonfragmented (P < .001) and sank (P < .001) showed correlation with being diagnostic, but needle visualization within the lesion did not. CONCLUSION: A minimum of four specimens, preferably those that are nonfragmented and that sink, should be obtained with 14-gauge US-guided breast biopsy.

AB - PURPOSE: To analyze the diagnostic yield for each specimen obtained at 14-gauge ultrasonography (US)-guided breast biopsy and compare these findings with mass, procedural, and specimen characteristics that could affect yield. MATERIALS AND METHODS: Seventy-three consecutive biopsies of breast masses were performed by using a 14-gauge handheld biopsy device. Each specimen was graded for whether it was nonfragmented or fragmented and for whether it sank or floated, and each pass was graded for whether or not the needle passed through the lesion. Each specimen was mounted on a separate slide. A pathologist who was unaware of the final diagnoses reviewed the slides in random order. A diagnosis was determined for each specimen whenever possible, and diagnostic yield was calculated as a function of number of passes. The Fisher exact test was used to compare yield for different specimen characteristics. RESULTS: Fourteen (19%) lesions were malignant and 59 (81%) were benign. Cells indicating the final diagnosis were contained in 249 (75%) of 334 specimens. Cells indicating the diagnosis were contained in the first specimen in 51 (70%) lesions, in the second specimen in 67 (92%), in the third specimen in 70 (96%), and in the fourth specimen in 73 (100%). Of the 14 malignancies, 13 (93%) were diagnosed with cells contained in the first or second specimen; one cancer (ductal carcinoma in situ) was diagnosed with cells contained in the fourth specimen. Specimens that were nonfragmented (P < .001) and sank (P < .001) showed correlation with being diagnostic, but needle visualization within the lesion did not. CONCLUSION: A minimum of four specimens, preferably those that are nonfragmented and that sink, should be obtained with 14-gauge US-guided breast biopsy.

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