Urothelial trauma - A mechanism of tumor promotion?

Yair Walzer, Robert B. Matheny, Anthony F. Blatnik, Mark S. Soloway

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Multistage carcinogenesis involves both tumor initiation and promotion. This study was undertaken to investigate whether urothelial trauma is an effective promoting agent. One hundred and ninety mice were maintained on a diet of 0.1% FANFT. Forty animals served as controls and three groups of animals underwent bladder catherization and urothelial trauma at periodic intervals beginning at week 19. The experiment was terminated at week 49. The data revealed no significant difference in the incidence of tumors in any group. There was, however, a greater incidence of invasive tumors in the groups undergoing urothelial trauma (Group II, 30%; Group III, 39%; Group IV, 57%) compared with the controls (25%). Trauma may, therefore, have some role in the promotion of tumors. Further studies are in progress to better define the role of urothelial trauma and its possible relevance to clinical recurrence of transitional cell carcinoma following transurethral resection.

Original languageEnglish
Pages (from-to)100-102
Number of pages3
JournalWorld Journal of Urology
Volume1
Issue number2
DOIs
StatePublished - Jun 1 1983
Externally publishedYes

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Wounds and Injuries
Neoplasms
FANFT
Transitional Cell Carcinoma
Incidence
Carcinogenesis
Urinary Bladder
Diet
Recurrence
Control Groups

ASJC Scopus subject areas

  • Urology

Cite this

Walzer, Y., Matheny, R. B., Blatnik, A. F., & Soloway, M. S. (1983). Urothelial trauma - A mechanism of tumor promotion? World Journal of Urology, 1(2), 100-102. https://doi.org/10.1007/BF00326753

Urothelial trauma - A mechanism of tumor promotion? / Walzer, Yair; Matheny, Robert B.; Blatnik, Anthony F.; Soloway, Mark S.

In: World Journal of Urology, Vol. 1, No. 2, 01.06.1983, p. 100-102.

Research output: Contribution to journalArticle

Walzer, Y, Matheny, RB, Blatnik, AF & Soloway, MS 1983, 'Urothelial trauma - A mechanism of tumor promotion?', World Journal of Urology, vol. 1, no. 2, pp. 100-102. https://doi.org/10.1007/BF00326753
Walzer Y, Matheny RB, Blatnik AF, Soloway MS. Urothelial trauma - A mechanism of tumor promotion? World Journal of Urology. 1983 Jun 1;1(2):100-102. https://doi.org/10.1007/BF00326753
Walzer, Yair ; Matheny, Robert B. ; Blatnik, Anthony F. ; Soloway, Mark S. / Urothelial trauma - A mechanism of tumor promotion?. In: World Journal of Urology. 1983 ; Vol. 1, No. 2. pp. 100-102.
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