Urothelial susceptibility to tumor cell implantation influence of cauterization

Mark S. Soloway, Steven Masters

Research output: Contribution to journalArticle

164 Scopus citations

Abstract

In an effort to determine whether tumor cells will preferentially implant on the cauterized urothelial surface, a reproducible technique for cauterization of a portion of the murine bladder was established. This technique simulates a transurethral fulguration of a bladder tumor in humans. Transplantable tumor cells (1 x 106) were placed transurethrally into the bladder of 50 mice. Twenty-five of these mice each had a portion of their bladder cauterized prior to insertion of tumor cells. Implantation with subsequent tumors occurred in 54% of mice with cauterization, in contrast to 12% of mice with an intact urothelial surface (P<0.005). Intravesical thio-tepa, mitomycin C, and cis-platinum were capable of significantly reducing the incidence of implantation. These results suggest that seeding may be a contributing factor to the high recurrence rate following endoscopic resection of fulguration of bladder tumors and that intravesical chemotherapy initiated shortly after surgery may reduce the incidence of implantation.

Original languageEnglish (US)
Pages (from-to)1158-1163
Number of pages6
JournalCancer
Volume46
Issue number5
DOIs
StatePublished - Sep 1 1980

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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