Urothelial susceptibility to tumor cell implantation: comparison of cauterization with N-methyl-N-nitrosourea

Mark S. Soloway, Israel Nissenkorn, Lee McCallum

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Abstract

To determine whether or not transitional cell carcinoma cells will preferentially implant and grow on an altered urothelial surface, cauterization and instillation of N-methyl-N-nitrosourea (MNU) were used to alter the murine bladder urothelium. Transplantable tumor cells (2.09 × 106) were placed into the bladders of 53 mice. Tumor cell implantation occurred in only 6 per cent of the mice with a normal bladder, whereas tumors were present in 28 per cent of mice pretreated with intravesical MNU and in 67 per cent of mice which had a portion of the bladder cauterized prior to insertion of tumor cells (p < 0.005). This study not only establishes the optimal technique for implantation in this experimental model, but also suggests that seeding may be a contributory factor in the high recurrence rate following endoscopic treatment of bladder tumors in man.

Original languageEnglish
Pages (from-to)159-161
Number of pages3
JournalUrology
Volume21
Issue number2
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

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ASJC Scopus subject areas

  • Urology

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