Abstract
Although it is frequently stated that one reason for postsurgical recurrence of transitional cell carcinoma is tumor cell implantation or ''seeding,'' there have been little objective data to support this theory. In the animal model used in this study normal and inflamed urothelium were exposed to a single cell suspension of a transitional cell tumor. The data clearly show that these neoplastic cells have the ability to adhere and establish tumor growth and that mucosal damage facilitates this process. It only remains to be determined how great a role this plays in man. Recurrent tumor development as a result of implantation might be preventable, and steps should be taken to limit its occurrence.
| Original language | English |
|---|---|
| Pages (from-to) | 547-549 |
| Number of pages | 3 |
| Journal | Surgical Forum |
| Volume | Vol. 25 |
| State | Published - Dec 1 1974 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Surgery
Cite this
Urothelial susceptibility to neoplastic cellular implantation. / Weldon, T. E.; Soloway, M. S.; Persky, L.
In: Surgical Forum, Vol. Vol. 25, 01.12.1974, p. 547-549.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Urothelial susceptibility to neoplastic cellular implantation
AU - Weldon, T. E.
AU - Soloway, M. S.
AU - Persky, L.
PY - 1974/12/1
Y1 - 1974/12/1
N2 - Although it is frequently stated that one reason for postsurgical recurrence of transitional cell carcinoma is tumor cell implantation or ''seeding,'' there have been little objective data to support this theory. In the animal model used in this study normal and inflamed urothelium were exposed to a single cell suspension of a transitional cell tumor. The data clearly show that these neoplastic cells have the ability to adhere and establish tumor growth and that mucosal damage facilitates this process. It only remains to be determined how great a role this plays in man. Recurrent tumor development as a result of implantation might be preventable, and steps should be taken to limit its occurrence.
AB - Although it is frequently stated that one reason for postsurgical recurrence of transitional cell carcinoma is tumor cell implantation or ''seeding,'' there have been little objective data to support this theory. In the animal model used in this study normal and inflamed urothelium were exposed to a single cell suspension of a transitional cell tumor. The data clearly show that these neoplastic cells have the ability to adhere and establish tumor growth and that mucosal damage facilitates this process. It only remains to be determined how great a role this plays in man. Recurrent tumor development as a result of implantation might be preventable, and steps should be taken to limit its occurrence.
UR - http://www.scopus.com/inward/record.url?scp=0016164095&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016164095&partnerID=8YFLogxK
M3 - Article
C2 - 4439255
AN - SCOPUS:0016164095
VL - Vol. 25
SP - 547
EP - 549
JO - Surgical Forum
JF - Surgical Forum
SN - 0071-8041
ER -