Urinary kallikrein activity and renal vascular resistance in the antihypertensive response to thiazide diuretics

Daniel T. O'connor, Richard A. Preston, John A. Mitas, Ronald P. Frigon, Richard A. Stone

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

To evaluate the mechanism of chronic thiazide diuretic action in hypertension, we treated 19 essential hypertensive white men for 1-month periods on placebo alone and hydrochlorothiazide alone. During therapy, mean arterial pressure (MAP) fell, but radioisotopically determined intravascular volume remained unchanged, suggesting other mechanisms of thiazide action upon blood pressure. In the renal circulation, thiazides did not change renal plasma flow or glomerular filtration rate, but renovascular resistance was diminished, probably at the afferent arteriole. Concomitant with the decline in blood pressure and renovascular resistance, urinary kallikrein excretion increased, from subnormal (hypertensive) levels back into the normal range. The kallikrein increase did not correlate with changes in plasma aldosterone. In addition, patients with blood pressure responses (reduction ≥ 10%) to thiazides (n=12) had greater increases in kallikrein excretion than those without such a blood pressure decrement (n=7), suggesting a role for renal kallikrein in the hypotensive response to thiazide diuretics.

Original languageEnglish (US)
Pages (from-to)139-147
Number of pages9
JournalHypertension
Volume3
Issue number1
DOIs
StatePublished - Jan 1 1981
Externally publishedYes

Keywords

  • Hypertension
  • Kallikrein
  • Plasma volume
  • Renal blood flow
  • Renal vascular resistance
  • Thiazide diuretics

ASJC Scopus subject areas

  • Internal Medicine

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