Urinary kallikrein activity and renal vascular resistance in the antihypertensive response to thiazide diuretics

D. T. O'Connor, Richard A Preston, J. A. Mitas, R. P. Frigon, R. A. Stone

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

To evaluate the mechanism of chronic thiazide diuretic action in hypertension, we treated 19 essential hypertensive white men for 1-month periods on placebo alone and hydrochlorothiazide alone. During therapy, mean arterial pressure (MAP) fell, but radioisotopically determined intravascular volume remained unchanged, suggesting other mechanisms of thiazide action upon blood pressure. In the renal circulation, thiazides did not change renal plasma flow or glomerular filtration rate, but renovascular resistance was diminished, probably at the afferent arteriole. Concomitant with the decline in blood pressure and renovascular resistance, urinary kallikrein excretion increased, from subnormal (hypertensive) levels back into the normal range. The kallikrein increase did not correlate with changes in plasma aldosterone. In addition, patients with blood pressure responses (reduction ≥ 10%) to thiazides (n=12) had greater increases in kallikrein excretion than those without such a blood pressure decrement (n=7), suggesting a role for renal kallikrein in the hypotensive response to thiazide diuretics.

Original languageEnglish
Pages (from-to)139-147
Number of pages9
JournalHypertension
Volume3
Issue number1
StatePublished - Aug 7 1981
Externally publishedYes

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Sodium Chloride Symporter Inhibitors
Tissue Kallikreins
Thiazides
Vascular Resistance
Antihypertensive Agents
Kallikreins
Blood Pressure
Kidney
Renal Plasma Flow
Hydrochlorothiazide
Renal Circulation
Arterioles
Aldosterone
Glomerular Filtration Rate
Arterial Pressure
Reference Values
Placebos
Hypertension

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Urinary kallikrein activity and renal vascular resistance in the antihypertensive response to thiazide diuretics. / O'Connor, D. T.; Preston, Richard A; Mitas, J. A.; Frigon, R. P.; Stone, R. A.

In: Hypertension, Vol. 3, No. 1, 07.08.1981, p. 139-147.

Research output: Contribution to journalArticle

O'Connor, D. T. ; Preston, Richard A ; Mitas, J. A. ; Frigon, R. P. ; Stone, R. A. / Urinary kallikrein activity and renal vascular resistance in the antihypertensive response to thiazide diuretics. In: Hypertension. 1981 ; Vol. 3, No. 1. pp. 139-147.
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