Urinary and erectile dysfunction in Multiple System Atrophy (MSA)

A. G. Papatsoris, S. Papapetropoulos, Carlos Singer, C. Deliveliotis

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Multiple system atrophy (MSA) is a neurodegenerative disease of undetermined etiology that occurs sporadically and manifests itself as a combination of parkinsonian, autonomic, cerebellar, and pyramidal signs. Despite the lack of effective therapies, some of the symptoms may be, at least temporarily, improved with adequate symptomatic therapies. Urinary and erectile dysfunction (ED) symptoms are prominent early features in male MSA patients. Lower urinary tract infections (UTIs) are a major cause of morbidity and mortality in this disorder. More than 50% of MSA patients suffer from recurrent lower UTIs and a significant number (∼25%) die of complications related to them. Urogenital symptoms in MSA are usually due to a complex mixture of central and peripheral nervous abnormalities, sometimes superimposed on previous local pathological conditions such as benign prostatic hyperplasia and perineal laxity. There have been instances were MSA-related urological symptoms were confused with symptoms of benign prostatic hyperplasia, leading to unnecessary urological surgery. In this review, we present the phenotypic range and therapeutic approaches for common storage and voiding urological symptoms and ED, in patients with MSA.

Original languageEnglish
Pages (from-to)22-27
Number of pages6
JournalNeurourology and Urodynamics
Volume27
Issue number1
DOIs
StatePublished - Jan 14 2008

Fingerprint

Multiple System Atrophy
Erectile Dysfunction
Prostatic Hyperplasia
Urinary Tract Infections
Unnecessary Procedures
Complex Mixtures
Neurodegenerative Diseases
Therapeutics
Morbidity
Mortality

Keywords

  • Erectile dysfunction
  • Multiple system atrophy
  • Review
  • Treatment algorithm
  • Urinary dysfunction

ASJC Scopus subject areas

  • Clinical Neurology
  • Nephrology
  • Urology

Cite this

Urinary and erectile dysfunction in Multiple System Atrophy (MSA). / Papatsoris, A. G.; Papapetropoulos, S.; Singer, Carlos; Deliveliotis, C.

In: Neurourology and Urodynamics, Vol. 27, No. 1, 14.01.2008, p. 22-27.

Research output: Contribution to journalArticle

Papatsoris, AG, Papapetropoulos, S, Singer, C & Deliveliotis, C 2008, 'Urinary and erectile dysfunction in Multiple System Atrophy (MSA)', Neurourology and Urodynamics, vol. 27, no. 1, pp. 22-27. https://doi.org/10.1002/nau.20461
Papatsoris, A. G. ; Papapetropoulos, S. ; Singer, Carlos ; Deliveliotis, C. / Urinary and erectile dysfunction in Multiple System Atrophy (MSA). In: Neurourology and Urodynamics. 2008 ; Vol. 27, No. 1. pp. 22-27.
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