Uricolysis by human leucocytes

R. Howell, J. E. Seegmiller

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

ALTHOUGH uricase is absent from the tissues of the human being, there is nevertheless evidence that uric acid is destroyed in man. Benedict, Forsham and Stetten1 first demonstrated by intravenous injection of isotopically labelled urate that only two-thirds to three-fourths of the daily urate turn-over of the body actually appears as urinary uric acid. Furthermore, the total recovery of the injected isotopically labelled uric acid in urinary uric acid over a 7-day period is similarly reduced2. The missing isotope has been demonstrated in a variety of metabolites in the urine, including ammonia, urea, allantoin, allantoic acid, respiratory carbon dioxide and fæcal bacterial bodies, after intravenous administration of uric acid labelled with nitrogen-15 and uric acid-2-14C (refs. 3, 4).

Original languageEnglish
Pages (from-to)482-483
Number of pages2
JournalNature
Volume196
Issue number4853
DOIs
StatePublished - Dec 1 1962
Externally publishedYes

Fingerprint

Uric Acid
Leukocytes
Allantoin
Urate Oxidase
Ammonia
Carbon Dioxide
Intravenous Injections
Isotopes
Intravenous Administration
Urea
Nitrogen
Urine

ASJC Scopus subject areas

  • General

Cite this

Howell, R., & Seegmiller, J. E. (1962). Uricolysis by human leucocytes. Nature, 196(4853), 482-483. https://doi.org/10.1038/196482a0

Uricolysis by human leucocytes. / Howell, R.; Seegmiller, J. E.

In: Nature, Vol. 196, No. 4853, 01.12.1962, p. 482-483.

Research output: Contribution to journalArticle

Howell, R & Seegmiller, JE 1962, 'Uricolysis by human leucocytes', Nature, vol. 196, no. 4853, pp. 482-483. https://doi.org/10.1038/196482a0
Howell R, Seegmiller JE. Uricolysis by human leucocytes. Nature. 1962 Dec 1;196(4853):482-483. https://doi.org/10.1038/196482a0
Howell, R. ; Seegmiller, J. E. / Uricolysis by human leucocytes. In: Nature. 1962 ; Vol. 196, No. 4853. pp. 482-483.
@article{1338b460ec0143c184c3a7a90678ef70,
title = "Uricolysis by human leucocytes",
abstract = "ALTHOUGH uricase is absent from the tissues of the human being, there is nevertheless evidence that uric acid is destroyed in man. Benedict, Forsham and Stetten1 first demonstrated by intravenous injection of isotopically labelled urate that only two-thirds to three-fourths of the daily urate turn-over of the body actually appears as urinary uric acid. Furthermore, the total recovery of the injected isotopically labelled uric acid in urinary uric acid over a 7-day period is similarly reduced2. The missing isotope has been demonstrated in a variety of metabolites in the urine, including ammonia, urea, allantoin, allantoic acid, respiratory carbon dioxide and f{\ae}cal bacterial bodies, after intravenous administration of uric acid labelled with nitrogen-15 and uric acid-2-14C (refs. 3, 4).",
author = "R. Howell and Seegmiller, {J. E.}",
year = "1962",
month = "12",
day = "1",
doi = "10.1038/196482a0",
language = "English",
volume = "196",
pages = "482--483",
journal = "Nature",
issn = "0028-0836",
publisher = "Nature Publishing Group",
number = "4853",

}

TY - JOUR

T1 - Uricolysis by human leucocytes

AU - Howell, R.

AU - Seegmiller, J. E.

PY - 1962/12/1

Y1 - 1962/12/1

N2 - ALTHOUGH uricase is absent from the tissues of the human being, there is nevertheless evidence that uric acid is destroyed in man. Benedict, Forsham and Stetten1 first demonstrated by intravenous injection of isotopically labelled urate that only two-thirds to three-fourths of the daily urate turn-over of the body actually appears as urinary uric acid. Furthermore, the total recovery of the injected isotopically labelled uric acid in urinary uric acid over a 7-day period is similarly reduced2. The missing isotope has been demonstrated in a variety of metabolites in the urine, including ammonia, urea, allantoin, allantoic acid, respiratory carbon dioxide and fæcal bacterial bodies, after intravenous administration of uric acid labelled with nitrogen-15 and uric acid-2-14C (refs. 3, 4).

AB - ALTHOUGH uricase is absent from the tissues of the human being, there is nevertheless evidence that uric acid is destroyed in man. Benedict, Forsham and Stetten1 first demonstrated by intravenous injection of isotopically labelled urate that only two-thirds to three-fourths of the daily urate turn-over of the body actually appears as urinary uric acid. Furthermore, the total recovery of the injected isotopically labelled uric acid in urinary uric acid over a 7-day period is similarly reduced2. The missing isotope has been demonstrated in a variety of metabolites in the urine, including ammonia, urea, allantoin, allantoic acid, respiratory carbon dioxide and fæcal bacterial bodies, after intravenous administration of uric acid labelled with nitrogen-15 and uric acid-2-14C (refs. 3, 4).

UR - http://www.scopus.com/inward/record.url?scp=0006172150&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0006172150&partnerID=8YFLogxK

U2 - 10.1038/196482a0

DO - 10.1038/196482a0

M3 - Article

C2 - 13955166

AN - SCOPUS:0006172150

VL - 196

SP - 482

EP - 483

JO - Nature

JF - Nature

SN - 0028-0836

IS - 4853

ER -