Upregulation of human immunodeficiency virus (HIV) replication by CD4 cross-linking in peripheral blood mononuclear cells of HIV-infected adults

S. Than, N. Oyaizu, S. Tetali, J. Romano, M. Kaplan, S. Pahwa

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

This study was conducted with peripheral blood mononuclear cells from 67 human immunodeficiency virus (HIV)-infected adults. It supports the hypothesis that cross-linking of CD4 molecules by HIV gp120 can result in HIV upregulation and spread of infection. Underlying mechanisms include activation of latent infection by factors in addition to, or other than, tumor necrosis factor alpha.

Original languageEnglish (US)
Pages (from-to)6230-6232
Number of pages3
JournalJournal of virology
Volume71
Issue number8
StatePublished - Aug 2 1997
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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