Upregulation of glial clusterin in brains of patients with AIDs

Jorge E. Torres-Muoz, Maximino Redondo, Catherine Czeisler, Brenda Roberts, Noe Tacoronte, Carol Petito

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Since clusterin (CLU) production in reactive astrocytes may be neuroprotective, we examined its distribution in AIDS brains where brain injury and reactive astrocytosis are common. The relative area and number of CLU-positive astrocytes, as well as their percent total of all white matter glia, significantly increased in AIDS brains with and without HIV encephalitis (P<0.05). Proliferation markers were absent. In contrast, the relative area and number of GFAP-positive astrocytes and their percent of all white matter glia, increased in some cases but the mean increases were not significant. Clusterin is sensitive marker of glial reactivity in AIDS brains and its enhanced expression was not dependent on increases in GFAP.

Original languageEnglish
Pages (from-to)297-301
Number of pages5
JournalBrain Research
Volume888
Issue number2
DOIs
StatePublished - Jan 12 2001

Fingerprint

Clusterin
Neuroglia
Astrocytes
Acquired Immunodeficiency Syndrome
Up-Regulation
Brain
Gliosis
Encephalitis
Brain Injuries
HIV
White Matter

Keywords

  • AIDS
  • Astrocyte
  • Clusterin
  • Glial fibrillary acidic protein
  • Gliosis

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Torres-Muoz, J. E., Redondo, M., Czeisler, C., Roberts, B., Tacoronte, N., & Petito, C. (2001). Upregulation of glial clusterin in brains of patients with AIDs. Brain Research, 888(2), 297-301. https://doi.org/10.1016/S0006-8993(00)03052-3

Upregulation of glial clusterin in brains of patients with AIDs. / Torres-Muoz, Jorge E.; Redondo, Maximino; Czeisler, Catherine; Roberts, Brenda; Tacoronte, Noe; Petito, Carol.

In: Brain Research, Vol. 888, No. 2, 12.01.2001, p. 297-301.

Research output: Contribution to journalArticle

Torres-Muoz, JE, Redondo, M, Czeisler, C, Roberts, B, Tacoronte, N & Petito, C 2001, 'Upregulation of glial clusterin in brains of patients with AIDs', Brain Research, vol. 888, no. 2, pp. 297-301. https://doi.org/10.1016/S0006-8993(00)03052-3
Torres-Muoz JE, Redondo M, Czeisler C, Roberts B, Tacoronte N, Petito C. Upregulation of glial clusterin in brains of patients with AIDs. Brain Research. 2001 Jan 12;888(2):297-301. https://doi.org/10.1016/S0006-8993(00)03052-3
Torres-Muoz, Jorge E. ; Redondo, Maximino ; Czeisler, Catherine ; Roberts, Brenda ; Tacoronte, Noe ; Petito, Carol. / Upregulation of glial clusterin in brains of patients with AIDs. In: Brain Research. 2001 ; Vol. 888, No. 2. pp. 297-301.
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