Upregulation of glial clusterin in brains of patients with AIDs

Jorge E. Torres-Muoz, Maximino Redondo, Catherine Czeisler, Brenda Roberts, Noe Tacoronte, Carol K. Petito

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Since clusterin (CLU) production in reactive astrocytes may be neuroprotective, we examined its distribution in AIDS brains where brain injury and reactive astrocytosis are common. The relative area and number of CLU-positive astrocytes, as well as their percent total of all white matter glia, significantly increased in AIDS brains with and without HIV encephalitis (P<0.05). Proliferation markers were absent. In contrast, the relative area and number of GFAP-positive astrocytes and their percent of all white matter glia, increased in some cases but the mean increases were not significant. Clusterin is sensitive marker of glial reactivity in AIDS brains and its enhanced expression was not dependent on increases in GFAP.

Original languageEnglish (US)
Pages (from-to)297-301
Number of pages5
JournalBrain Research
Volume888
Issue number2
DOIs
StatePublished - Jan 12 2001

Keywords

  • AIDS
  • Astrocyte
  • Clusterin
  • Glial fibrillary acidic protein
  • Gliosis

ASJC Scopus subject areas

  • Neuroscience(all)

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    Torres-Muoz, J. E., Redondo, M., Czeisler, C., Roberts, B., Tacoronte, N., & Petito, C. K. (2001). Upregulation of glial clusterin in brains of patients with AIDs. Brain Research, 888(2), 297-301. https://doi.org/10.1016/S0006-8993(00)03052-3