Upregulation of glial clusterin in brains of patients with AIDs

Jorge E. Torres-Muoz; Maximino Redondo; Catherine Czeisler; Brenda Roberts; Noe Tacoronte; Carol K. Petito

doi:10.1016/S0006-8993(00)03052-3

Upregulation of glial clusterin in brains of patients with AIDs

Jorge E. Torres-Muoz, Maximino Redondo, Catherine Czeisler, Brenda Roberts, Noe Tacoronte, Carol K. Petito

Pathology

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Since clusterin (CLU) production in reactive astrocytes may be neuroprotective, we examined its distribution in AIDS brains where brain injury and reactive astrocytosis are common. The relative area and number of CLU-positive astrocytes, as well as their percent total of all white matter glia, significantly increased in AIDS brains with and without HIV encephalitis (P<0.05). Proliferation markers were absent. In contrast, the relative area and number of GFAP-positive astrocytes and their percent of all white matter glia, increased in some cases but the mean increases were not significant. Clusterin is sensitive marker of glial reactivity in AIDS brains and its enhanced expression was not dependent on increases in GFAP.

Original language	English (US)
Pages (from-to)	297-301
Number of pages	5
Journal	Brain Research
Volume	888
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(00)03052-3
State	Published - Jan 12 2001

Keywords

AIDS
Astrocyte
Clusterin
Glial fibrillary acidic protein
Gliosis

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/S0006-8993(00)03052-3

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title = "Upregulation of glial clusterin in brains of patients with AIDs",

abstract = "Since clusterin (CLU) production in reactive astrocytes may be neuroprotective, we examined its distribution in AIDS brains where brain injury and reactive astrocytosis are common. The relative area and number of CLU-positive astrocytes, as well as their percent total of all white matter glia, significantly increased in AIDS brains with and without HIV encephalitis (P<0.05). Proliferation markers were absent. In contrast, the relative area and number of GFAP-positive astrocytes and their percent of all white matter glia, increased in some cases but the mean increases were not significant. Clusterin is sensitive marker of glial reactivity in AIDS brains and its enhanced expression was not dependent on increases in GFAP.",

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AU - Torres-Muoz, Jorge E.

AU - Redondo, Maximino

AU - Czeisler, Catherine

AU - Roberts, Brenda

AU - Tacoronte, Noe

AU - Petito, Carol K.

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AB - Since clusterin (CLU) production in reactive astrocytes may be neuroprotective, we examined its distribution in AIDS brains where brain injury and reactive astrocytosis are common. The relative area and number of CLU-positive astrocytes, as well as their percent total of all white matter glia, significantly increased in AIDS brains with and without HIV encephalitis (P<0.05). Proliferation markers were absent. In contrast, the relative area and number of GFAP-positive astrocytes and their percent of all white matter glia, increased in some cases but the mean increases were not significant. Clusterin is sensitive marker of glial reactivity in AIDS brains and its enhanced expression was not dependent on increases in GFAP.

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