Upregulation of β-amyloid precursor protein expression in glioblastoma multiforme

Frank Culicchia, Jian Guo Cui, Yuan Yuan Li, Walter J. Lukiw

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Glioma and glioblastoma multiforme constitute rapidly proliferating glial cell tumors whose pathogenic mechanisms are not well understood. This study examined proinflammatory and neurodegenerative gene expression in five American Tissue Culture Collection glioma and glioblastoma multiforme tumor cell lines and in 14 glioma and glioblastoma samples obtained from human brain biopsy. Expression of the low-abundance cyclooxygenase-1 and the high-abundance cytoskeletal element β-actin were found not to significantly change in any cells or tissues studied and were used as internal controls. In contrast, proinflammatory cyclooxygenase-2, cytosolic phospholipase A2, IL-1β, and β-amyloid precursor protein expression levels were found to be significantly upregulated. These studies suggest that glioma and glioblastoma exhibit robust upregulation of proinflammatory and neurodegenerative genetic markers that may contribute to the pathobiology, phenotype, and proliferation of glial cell growth.

Original languageEnglish
Pages (from-to)981-985
Number of pages5
JournalNeuroReport
Volume19
Issue number9
DOIs
StatePublished - Jun 11 2008

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Keywords

  • β-amyloid precursor protein
  • Alzheimer's disease
  • Biopsy
  • Cyclooxygenase
  • Cyclooxygenase-1, cyclooxygenase-2
  • Cytosolic phospholipase A2
  • Glioblastoma
  • Glioma
  • IL-1β
  • Inflammation

ASJC Scopus subject areas

  • Neuroscience(all)

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