Upregulation of β-amyloid precursor protein expression in glioblastoma multiforme

Frank Culicchia, Jian Guo Cui, Yuan Yuan Li, Walter J. Lukiw

Research output: Contribution to journalArticle

9 Citations (Scopus)


Glioma and glioblastoma multiforme constitute rapidly proliferating glial cell tumors whose pathogenic mechanisms are not well understood. This study examined proinflammatory and neurodegenerative gene expression in five American Tissue Culture Collection glioma and glioblastoma multiforme tumor cell lines and in 14 glioma and glioblastoma samples obtained from human brain biopsy. Expression of the low-abundance cyclooxygenase-1 and the high-abundance cytoskeletal element β-actin were found not to significantly change in any cells or tissues studied and were used as internal controls. In contrast, proinflammatory cyclooxygenase-2, cytosolic phospholipase A2, IL-1β, and β-amyloid precursor protein expression levels were found to be significantly upregulated. These studies suggest that glioma and glioblastoma exhibit robust upregulation of proinflammatory and neurodegenerative genetic markers that may contribute to the pathobiology, phenotype, and proliferation of glial cell growth.

Original languageEnglish
Pages (from-to)981-985
Number of pages5
Issue number9
StatePublished - Jun 11 2008


Amyloid beta-Protein Precursor
Cytosolic Phospholipases A2
Amyloidogenic Proteins
Cyclooxygenase 1
Cyclooxygenase 2
Tumor Cell Line
Genetic Markers
Gene Expression


  • β-amyloid precursor protein
  • Alzheimer's disease
  • Biopsy
  • Cyclooxygenase
  • Cyclooxygenase-1, cyclooxygenase-2
  • Cytosolic phospholipase A2
  • Glioblastoma
  • Glioma
  • IL-1β
  • Inflammation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Upregulation of β-amyloid precursor protein expression in glioblastoma multiforme. / Culicchia, Frank; Cui, Jian Guo; Li, Yuan Yuan; Lukiw, Walter J.

In: NeuroReport, Vol. 19, No. 9, 11.06.2008, p. 981-985.

Research output: Contribution to journalArticle

Culicchia, Frank ; Cui, Jian Guo ; Li, Yuan Yuan ; Lukiw, Walter J. / Upregulation of β-amyloid precursor protein expression in glioblastoma multiforme. In: NeuroReport. 2008 ; Vol. 19, No. 9. pp. 981-985.
title = "Upregulation of β-amyloid precursor protein expression in glioblastoma multiforme",
abstract = "LippincottWilliams & Wilkins.",
keywords = "β-amyloid precursor protein, Alzheimer's disease, Biopsy, Cyclooxygenase, Cyclooxygenase-1, cyclooxygenase-2, Cytosolic phospholipase A2, Glioblastoma, Glioma, IL-1β, Inflammation",
author = "Frank Culicchia and Cui, {Jian Guo} and Li, {Yuan Yuan} and Lukiw, {Walter J.}",
year = "2008",
month = "6",
day = "11",
doi = "10.1097/WNR.0b013e328302f139",
language = "English",
volume = "19",
pages = "981--985",
journal = "NeuroReport",
issn = "0959-4965",
publisher = "Lippincott Williams and Wilkins",
number = "9",



T1 - Upregulation of β-amyloid precursor protein expression in glioblastoma multiforme

AU - Culicchia, Frank

AU - Cui, Jian Guo

AU - Li, Yuan Yuan

AU - Lukiw, Walter J.

PY - 2008/6/11

Y1 - 2008/6/11

N2 - LippincottWilliams & Wilkins.

AB - LippincottWilliams & Wilkins.

KW - β-amyloid precursor protein

KW - Alzheimer's disease

KW - Biopsy

KW - Cyclooxygenase

KW - Cyclooxygenase-1, cyclooxygenase-2

KW - Cytosolic phospholipase A2

KW - Glioblastoma

KW - Glioma

KW - IL-1β

KW - Inflammation

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UR - http://www.scopus.com/inward/citedby.url?scp=52249088245&partnerID=8YFLogxK

U2 - 10.1097/WNR.0b013e328302f139

DO - 10.1097/WNR.0b013e328302f139

M3 - Article

C2 - 18521005

AN - SCOPUS:52249088245

VL - 19

SP - 981

EP - 985

JO - NeuroReport

JF - NeuroReport

SN - 0959-4965

IS - 9

ER -