Upper airway obstruction and pulmonary abnormalities due to lymphoproliferative disease following bone marrow transplantation in children

Barry D. Fletcher, Helen E. Heslop, Sue C. Kaste, Sara Bodner

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We report three patients who developed severe supraglottic airway obstruction due to Epstein-Barr virus lymphoproliferative disease following allogeneic bone marrow transplantation. In addition to enlarged pharyngeal lymphoid tissue seen in all three patients, two had supraglottic airway narrowing and two developed pulmonary lymphoproliferative disease. They were treated with unmanipulated T cells or EBV-specific cytotoxic T lymphocytes. Life-threatening upper airway obstruction is a radiologically detectable complication of allogeneic bone marrow transplantation in children.

Original languageEnglish
Pages (from-to)492-496
Number of pages5
JournalPediatric Radiology
Volume28
Issue number7
DOIs
StatePublished - Jan 1 1998

Fingerprint

Homologous Transplantation
Airway Obstruction
Bone Marrow Transplantation
Human Herpesvirus 4
Lung
Cytotoxic T-Lymphocytes
Lymphoid Tissue
Virus Diseases
Lung Diseases
T-Lymphocytes

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Pediatrics, Perinatology, and Child Health
  • Radiological and Ultrasound Technology

Cite this

Upper airway obstruction and pulmonary abnormalities due to lymphoproliferative disease following bone marrow transplantation in children. / Fletcher, Barry D.; Heslop, Helen E.; Kaste, Sue C.; Bodner, Sara.

In: Pediatric Radiology, Vol. 28, No. 7, 01.01.1998, p. 492-496.

Research output: Contribution to journalArticle

Fletcher, Barry D. ; Heslop, Helen E. ; Kaste, Sue C. ; Bodner, Sara. / Upper airway obstruction and pulmonary abnormalities due to lymphoproliferative disease following bone marrow transplantation in children. In: Pediatric Radiology. 1998 ; Vol. 28, No. 7. pp. 492-496.
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