Updates in lymph node and skin pathology of adult T-cell leukemia/lymphoma, biomarkers, and beyond

Brian D. Adkins, Juan C. Ramos, Meghan Bliss-Moreau, Alejandro A. Gru

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

Adult T-cell leukemia/lymphoma (ATLL) is a mature T-cell lymphoproliferative disorder associated with the human T lymphotropic virus (HTLV-1) infection. ATLL predominantly affects individuals within HTLV-1 endemic areas such as Japan, areas of Africa, South America, and the Caribbean. HTLV-1 preferentially infects CD4+ T-cells, and several genetic hits must occur before ATLL develops. ATLL is classically divided into four clinical variants based on manifestations of disease: acute, chronic, lymphomatous, and smouldering. As of 2019, a new subtype has been described: lymphoma type of ATL, extranodal primary cutaneous. In this review, emphasis will be taken to describe the common clinicopathologic manifestations of the disease, advances in biomarker discovery, mutational landscape and targeted therapeutic approaches to treat this highly aggressive and frequently lethal type of T-cell lymphoma.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalSeminars in Diagnostic Pathology
Volume37
Issue number1
DOIs
StatePublished - Jan 2020

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

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