Updated investigations of the role of methylenetetrahydrofolate reductase in human neural tube defects

E. Rampersaud, E. C. Melvin, D. Siegel, L. Mehltretter, M. E. Dickerson, T. M. George, D. Enterline, J. S. Nye, Marcy C. Speer, Joanna Aben, Arthur Aylsworth, Cynthia Powell, Timothy Brei, Connie Buran, Joann Bodurtha, Kathleen Sawin, Mark S. Dias, Bermans Iskandar, Bonnie Ohm, Nicole LasarskyDavid McLone, Joy Ito, W. Jerry Oakes, Marion Walker, Paula Peterson

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Folate supplementation appears to reduce the risk for neural tube defects (NTDs). Methylenetetrahydrofolate reductase (MTHFR) is a candidate gene in the folate metabolism pathway that has been extensively studied in different human populations. We examined the risk associated with having the thermolabile variant (TT) of MTHFR in a study of 175 American Caucasians with NTDs and their families. We found a significant association in patients compared with 195 unrelated controls [odds ratio (OR) = 2.13, 95 % confidence interval (95% CI) = 1.11-4.09)], but not in mothers (OR = 1.29, 95% CI = 0.622-2.67) or in fathers (OR = 1.45, 95% CI = 0.681-3.09). We found no evidence for unequal transmission from parents to an affected child (p > 0.10). We failed to find a previously reported association for a combined haplotype for MTHFR and cystathionine β-synthase, except in subjects with NTDs compared with 559 pooled controls (OR = 2.87, 95% CI = 1.03-8.03). We found no evidence for an association for a novel CA-repeat polymorphism identified in a gene closely linked to MTHFR (p > 0.10). Our studies continue to suggest that additional candidate genes other than MTHFR may be responsible for an increased risk to NTD in some American Caucasian families.

Original languageEnglish
Pages (from-to)210-214
Number of pages5
JournalClinical Genetics
Volume63
Issue number3
DOIs
StatePublished - Mar 1 2003

Fingerprint

Methylenetetrahydrofolate Reductase (NADPH2)
Neural Tube Defects
Odds Ratio
Confidence Intervals
Folic Acid
Cystathionine
Genes
Fathers
Haplotypes
Parents
Mothers
Population

Keywords

  • Cystathionine beta-synthase
  • Gene-environment interactions
  • Methylenetetrahydrofolate reductase
  • Neural tube defects

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Rampersaud, E., Melvin, E. C., Siegel, D., Mehltretter, L., Dickerson, M. E., George, T. M., ... Peterson, P. (2003). Updated investigations of the role of methylenetetrahydrofolate reductase in human neural tube defects. Clinical Genetics, 63(3), 210-214. https://doi.org/10.1034/j.1399-0004.2003.00043.x

Updated investigations of the role of methylenetetrahydrofolate reductase in human neural tube defects. / Rampersaud, E.; Melvin, E. C.; Siegel, D.; Mehltretter, L.; Dickerson, M. E.; George, T. M.; Enterline, D.; Nye, J. S.; Speer, Marcy C.; Aben, Joanna; Aylsworth, Arthur; Powell, Cynthia; Brei, Timothy; Buran, Connie; Bodurtha, Joann; Sawin, Kathleen; Dias, Mark S.; Iskandar, Bermans; Ohm, Bonnie; Lasarsky, Nicole; McLone, David; Ito, Joy; Oakes, W. Jerry; Walker, Marion; Peterson, Paula.

In: Clinical Genetics, Vol. 63, No. 3, 01.03.2003, p. 210-214.

Research output: Contribution to journalArticle

Rampersaud, E, Melvin, EC, Siegel, D, Mehltretter, L, Dickerson, ME, George, TM, Enterline, D, Nye, JS, Speer, MC, Aben, J, Aylsworth, A, Powell, C, Brei, T, Buran, C, Bodurtha, J, Sawin, K, Dias, MS, Iskandar, B, Ohm, B, Lasarsky, N, McLone, D, Ito, J, Oakes, WJ, Walker, M & Peterson, P 2003, 'Updated investigations of the role of methylenetetrahydrofolate reductase in human neural tube defects', Clinical Genetics, vol. 63, no. 3, pp. 210-214. https://doi.org/10.1034/j.1399-0004.2003.00043.x
Rampersaud, E. ; Melvin, E. C. ; Siegel, D. ; Mehltretter, L. ; Dickerson, M. E. ; George, T. M. ; Enterline, D. ; Nye, J. S. ; Speer, Marcy C. ; Aben, Joanna ; Aylsworth, Arthur ; Powell, Cynthia ; Brei, Timothy ; Buran, Connie ; Bodurtha, Joann ; Sawin, Kathleen ; Dias, Mark S. ; Iskandar, Bermans ; Ohm, Bonnie ; Lasarsky, Nicole ; McLone, David ; Ito, Joy ; Oakes, W. Jerry ; Walker, Marion ; Peterson, Paula. / Updated investigations of the role of methylenetetrahydrofolate reductase in human neural tube defects. In: Clinical Genetics. 2003 ; Vol. 63, No. 3. pp. 210-214.
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