Update on the search for DNA markers linked to manic-depressive illness in the old order amish

Edward I. Ginns, Janice A. Egeland, Cleona R. Allen, David L. Pauls, Kathleen Falls, Tim P. Keith, Steven M. Paul

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

In this report we describe our efforts to identify a gene involved in bipolar illness using a large, multigenerational Old Order Amish pedigree with many affected individials. The original collection of cell lines from Amish pedigree 110 has been extended to include 169 individuals. We have used over 250 markers spaced at approximately 20 centiMorgans that detect restriction length fragment polymorphisms, but no LOD scores greater than 3 have been obtained from pairwise linkage analyses. We are expanding our collection of cell lines from both normal and affected family members and updating our diagnostic data as we continue our systematic screening of the genome for a gene involved in bipolar illness.

Original languageEnglish (US)
Pages (from-to)305-308
Number of pages4
JournalJournal of Psychiatric Research
Volume26
Issue number4
DOIs
StatePublished - Oct 1992

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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